Objective To seek out the effective, simple, rapid methods of postmenopausal IUD removal difficulties. Methods 51 cases of post-menopausal IUD removal difficulties were randomly divided into two groups, 27 cases in Group A using misoprostol plus oral nylestriol and 24 cases in Group B using mifepristone plus oral misoprestol to compare the efficacy, side effects and use of time. Results Both A and B groups succeeded in IUD removal by con-ventional methods with the success rate of 100% and with the same effects. Group A at the first removal failure were taken oral nylestriol 2 mg, taking misopros-tol two days later at removal, with 2 cases of drag side effects (2/27, 7.4%) ; Taken four days for removal, Group B had drug side effects of 6 cases (6/24, 25%). The difference was significant (P<0.05). Conclusion Misuprostol + nilestrioland has the same effects with mifepristone + misoprostol for postmenopansal IUD removal difficulties, which have fewer side effects, are easier to take, and significantly reduces the time of medication.%目的 寻求绝经后IUD取出困难更有效、简易、快速的方法.方法 将51例绝经后IUD取出困难者随机分为甲乙两组,甲组27例用米索前列醇和尼尔雌醇口服,乙组24例用米非司酮加米索前列醇口服,比较两组用药后的疗效、药物副反应及用药时间.结果 用药后甲乙两组均经常规取环成功,取环成功率100%,疗效相同.甲组在首次取环失败后即予口服尼尔雌醇2 mg,两天后再取环时服用米索前列醇,出现药物副反应2例(2/27),发生率:7.4%;乙组服药4天取环,出现药物副反应6倒(6/24),发生率25%,两者比较差异有显著性(P<0.05).结论 时于绝经后IUD取出困难者用米索前列醇和尼尔雌醇与米非司酮加米索前列醇相同,前者药物副反应少,用药方式简便易行,明显缩短用药时间.
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