溃疡性结肠炎患者血清γ-干扰素、白细胞介素10(IL-10),IL-17、辅助性T细胞17表达的荟萃分析

摘要

目的 对溃疡性结肠炎患者外周血中γ-干扰素(IFN-γ)、白细胞介素10(IL-10)、白细胞介素17(IL-17)的水平和辅助性T细胞17(Th17)比例检测指标的意义进行评价.方法 计算机检索PubMed(1996～2016)、CBM(1998～2016)、CNKI(1958～2016)、WangfanData(1999～2016) 、VIP(1989～2016)等数据库,对溃疡性结肠炎患者血清IFN-γ、IL-10、IL-17水平和Th17细胞比例指标的随机对照试验(RCT)进行检索,并按照纳入与排除标准筛选文献、评价质量并提取资料后,采用RevMan5.3软件进行Meta分析.结果 共纳入20个RCT,1 151例患者.Meta分析结果显示:与对照组比较,溃疡性结肠炎患者外周血IFN-γ、IL 17、Th17上升;外周血IL-10下降.结论 IFN-γ、IL-10、IL-17水平和Th17细胞参与了溃疡性结肠炎的发病过程,有必要开展更深入的研究.%Objective To evaluate the association of interferon-γ(IFN-γ),interleukin-10(IL-10),interleukin-17 (IL-17) and helper cell T-17(Th17) cells proportion with ulcerative colitis (UC).Methods Analysis of all related literatures in PubMed (1996-2016),CBM (1998-2016),CNKI (1958-2016),WanfangData (1999-2016) and VIP (1989 2016) was made.Randomized controlled trials involving in serum IFN-γ,IL-10,IL-17 and Th17 cells proportion in UC patients were selected.All statistical tests were performed with RevManS.3 software.Results A total of 20 articles and 1 151 patients were included.The results indicated that IFN-γ in UC group was significantly higher than in control group.IL-10 in UC group was significantly lower than that in control group.IL-17 in UC group was significantly higher than that in control group.Th17 cells proportion in UC group was significantly higher than that in control group.Conclusion Existing evidences suggest that IFN-γ,IL-10,IL-17 and Th17 contribute to the pathogenesisi of UC.