Objective To investigate the influence of the fish oil fatty acid (rich in ω-3 polyunsaturated fatty acids ) acting on the cellular immune and inflammatory response of perioperative patients of gastrointestinal tumors .Methods 79 gastrointestinal tumors patients who took total parenteral nutrition (TPN)after operation are divided into 2 groups randomly(collected from July 2010 to June 2012) .39 patients in study group are supplied with fish oil fatty acid within 24 h after operation and 7 d in total .40 pa-tients in the control group are supplied with ordinary long chain fat emulsion within 24 h after operation ,7 d as a course .The per-centage and the ratio of T lymphocyte subsets(CD3 ,CD4 ,CD8) ,monocyte human leukocyte antigen DR(HLA-DR) expression(per-centage) and the number of monocytes of 2 groups were test by blood test at 1st and 8th day after operation .Results The ratio of CD3、CD4、CD8、CD4/CD8 ,monocyte(HLA-DR) expression(percentage) and the number of monocytes in the study group were sig-nificantly higher than that of control group after received fish oil fat emulsion (P<0 .05) .There was no significant difference be-tween two groups on the 1st day after operation of C reactive protein (CRP) ,interleukin-1β(IL-1β) ,IL-6) ,IL-2 and IL-12(P>0 .05) .However ,compared with their results shown that they all had obvious difference respectively by a eight-day observation(P<0 .05) .compared with the first day the CRP in the control group at 8th day after operation were significantly higher than that of the 1st day ,the study group at 8th day was obviously decreased ,the difference was statistically significant (P<0 .05);IL-1βand IL-6 of the two groups were decreased at 8th day after operation and the study group decreased more obviously than the control group (P<0 .05) .IL-2 and IL-12 of the 2 groups at 8th day after operation were decreased than that of the 1st day ,but the difference between the two groups was not statistically significant (P>0 .05) .Conclusion Given the fat emulsion of fish oil which is rich in ω-3 poly-unsaturated fatty acid can significantly improve the cellular immune function of postoperative patients and release the inflammatory response after operation in patients of gastrointestinal tumors .%目的：探讨鱼油脂肪乳剂（富含ω-3多不饱和脂肪酸）对胃肠道肿瘤术后患者细胞免疫及炎症反应的影响。方法将2010年7月至2012年6月79例胃肠道肿瘤术后行全肠外营养（T PN ）的患者分为两组，研究组39例，术后24 h内开始补充鱼油脂肪乳7d，对照组40例，术后24h内开始补充普通中长链脂肪乳7d。两组分别于术后第1天和第8天抽血检测T淋巴细胞亚群（CD3、CD4、CD8）百分比及比值，单核细胞人类白细胞DR抗原（HLA-DR）表达（百分比）和单核细胞数目。结果研究组CD3、CD4、CD8、CD4/CD8比值、单核细胞 HLA-DR表达（百分比）和单核细胞数目较对照组有明显上升，差异具有统计学意义（P＜0．05）；两组患者术后第1天C反应蛋白（CRP）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、白细胞介素-2（IL-2）和白细胞介素-12（IL-12）差异均无统计学意义（P＞0．05）。对照组CRP术后第8天较术后第1天明显升高，研究组术后第8天较第1天明显降低，差异有统计学意义（ P＜0．05）。两组患者IL-1β、IL-6水平术后第8天均下降，研究组比对照组下降更明显（ P＜0．05）。两组患者IL-2、IL-12术后第8天较第1天有所下降，但两组相比差异无统计学意义（ P＞0．05）。结论补充富含ω-3多不饱和脂肪酸的鱼油脂肪乳剂能明显改善术后患者细胞免疫功能。
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