目的：比较不同年龄组儿童癫痫性痉挛（ES ）患儿的临床、脑电图特点、对药物的反应及预后。方法对深圳儿童医院神经科2002年1月至2011年10月未发现明显病因（隐源性）的15岁以下癫痫性痉挛患儿的临床和EEG资料进行回顾性研究，其中选取74例有门诊随访资料、随访时间12～92个月的病例，按年龄分组，痉挛起病年龄3～＜12个月的为婴儿期发病的痉挛（IOS），60例；痉挛起病年龄12个月至7岁的为晚发型癫痫性痉挛（LOS），共14例。对两组病例的临床过程、发作形式、脑电图特点进行比较。结果两组患者发作表现相似，发作间期脑电图改变（放电区域、清醒时脑电背景）和对药物的反应有差异。结论婴儿期发病的痉挛和晚发型癫痫性痉挛在脑电图表现和对药物的反应方面有差异。%Objective To compare the clinical and electroencephalogram(EEG)characteristics and therapeutic response prognosis of different age groups of children with epileptic spasm .Methods From January 2002 to October 2011 the clinical data ,EEG fea-tures of epileptic spasms children under 15 years old with unknown disease cause(cryptogenic) were retrospectively reviewed .74 of them were followed up for 12 to 92 months .All of them were divided into two groups on the basis of onset age :3 -12 months of onset as group infantile-onset spasms(group IOS ,n=60);and 12 months to 7 years old of onset as group late-onset epileptic spasms (group LOS ,n=14) .Clinical process ,seizure semiology and EEG features were compared between two groups .Results Semiologic features of two groups were similar ,but they showed differences in interictal EEG features including the background ,the location of discharges ;The response to drugs between the two groups are also different .Conclusion There are differences between group IOS and group LOS when comparing EEG features and response to drugs .
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