高龄慢性阻塞性肺疾病急性加重期患者IL-8、IL-6、TNF-α水平变化与肺功能相关性研究

摘要

目的 探讨高龄慢性阻塞性肺疾病(COPD)急性加重期患者白细胞介素-8(IL-8)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平变化及与肺功能相关性的临床意义.方法 采集高龄COPD患者急性加重期及治疗后缓解期外周静脉血,检测IL-8、IL-6、TNF-α水平,采用肺功能检测仪检测两组患者FEV1％ pred的变化.结果 高龄COPD急性加重期细胞因子水平随综合评估分级递增而逐渐增加(P＜0.01)；急性加重期IL-8、IL-6、TNF-α水平明显高于缓解期组(P＜0.05)；急性加重期及缓解期IL-8、IL-6、TNF-α水平与肺功能指标FEV1％ pred呈负相关(P＜0.01).结论 高龄COPD患者IL-8、IL-6、TNF-α水平的变化可作为衡量高龄COPD患者病情严重程度和判断患者的疗效及预后的重要指标,且与肺功能负相关.%Objective To investigate clinical significance of correlation of pulmonary function and changes of IL-8,IL-6,TNF-α in senior patients with acute exacerbation of chronic obstructive pulmonary disease.Methods Peripheral venous blood was collected,IL-8,IL-6 and TNF-α was detected and FEV1％ pred was detected using pulmonary function detector in senior patients with COPD both in acute exacerbation and catabasis after treatment.Results Cytokine levels were gradually increased with increment of comprehensive assessment grading in senior patients with COPD in acute exacerbation(P＜0.01).The levels of IL-8,IL-6 and TNF-α were significantly higher in senior patients with COPD in acute exacerbation than in remission(P＜0.05).The levels of IL-8,IL-6,and TNF-α were negatively correlated with FEV1％ pred both in acute exacerbation and catabasis(P＜0.01).Conclusion The changes of IL-8,IL-6 and TNF-α in senior patients with COPD could be seemed as an important indicator for disease severity and prognosis of senior patients with COPD,and was negatively correlated with pulmonary function.