钙泊三醇倍他米松软膏外用治疗寻常性银屑病临床对照研究

摘要

Objective To observe the clinical efficacy and safety of calcipotriol betamethasone ointment for the treatment of pso‐riasis vulgaris in the stable stage of patient .Methods This was a randomized ,parallel controlled clinical trials ,in which 90 patients with psoriasis vulgaris were randomly divided into experimental group and controlled group .All of them received 4 weeks of thera‐py .We compared the efficacy and safety 1 ,2 ,4 week after treatment by calcipotriol betamethasone ointment .Results About the clinical efficacy ,according to the decrease in percentage of psoriasis area and severity index (PASI) were:23 patients in the experi‐mental group were effective(efficacy rate is 76 .67% ) ,14 patients in control group Ⅰ was effective(efficacy rate is 46 .67% ) ,15 pa‐tients in control group Ⅱ was effective(efficacy rate is 50% ) .The differention between experimental group and the two control groups was significant(P< 0 .05 ,P< 0 .01) .After 1 ,2 ,4 weeks of therapy ,the decrease in percentage of PASI of experimental group is higher than that in the control groups .The scores of the observed erythema ,infiltration ,scale were decreased ,and the total scores of PASI are also decreased 4 weeks after therapy .The decrease score of experimental group is higher than that of control group Ⅰ(P<0 .01) and control group Ⅱ(P<0 .01) .The side effects of the experimental group are mild such as itching ,folliculi‐tis ,erythema ,and the laboratory examinations had no abnormal changes .Conclusion Calcipotriol betamethasone ointment was more effective to treat the stable stage psoriasis vulgaris patients compared with single use of halometasone or calcipotriol .It takes effect quickly ,and could be more feasible and safe .%目的：探讨钙泊三醇倍他米松软膏外用治疗静止期寻常型银屑病患者的临床疗效和安全性。方法采用随机、阳性药物平行对照临床试验，入组90例静止期寻常型银屑病患者，随机纳入试验组或对照组，疗程4周。于治疗1、2、4周后比较试验组及对照组的临床疗效和安全性。结果临床疗效方面：3组寻常型银屑病患者治疗4周后银屑病面积和严重程度指数（PASI）评分下降百分比：试验组有效为23例（76．67％）、对照Ⅰ组有效14例（46．67％）、对照Ⅱ组有效15例（50．00％），试验组分别与两对照组比较，差异均有统计学意义（P＜0．05）。治疗1、2、4周后，试验组PASI评分下降百分比显著高于对照Ⅰ组和对照Ⅱ组，差异均有统计学意义（P＜0．05）。3组治疗1、2、4周后靶皮损红斑、浸润、鳞屑单独积分以及皮损总面积百分比，试验组的下降值均大于对照I组和对照Ⅱ组，差异有统计学意义（P＜0．05）。药物不良反应方面：主要为瘙痒、毛囊炎、红斑等局部症状，且症状轻微，实验室检查无异常变化。结论钙泊三醇倍他米松软膏治疗静止期寻常型银屑病的临床疗效优于单一使用卤米松或卡泊三醇，且起效快、方便给药、相对安全的特点。