冬虫夏草水煎剂联合顺铂对荷瘤小鼠抑瘤作用的实验研究

摘要

Objective To study the tumor suppression of Chinese caterpillar fungus water decoction combined cisplatin on a tumor burdened mice .Methods The beforehand vaccinal HCT8 tumor burdened mice were randomly devided into 5 groups(n=10) ,then 3 groups of Chinese caterpillar fungus water decoction were given a tumor burdened mice stomach (2 .5 ,5 .0 ,10 g/kg) ,1 times a day ,12 d .1 group of mice were given saline .1 group were given cisplatin .Determination of different concentrations of cordyceps water decoction lavage ,then observe the changes of tumor‐burdened bone tumors in mice weight .Results For vaccination HCT8 tumor burdened bone tumors had an average weight of each dose group mice compared with saline group have significant difference(P<0 .01) ,while Chinese caterpillar fungus water decoction (2 .5 ,5 .0 g/kg) and cisplatin group mice tumor block is more significant difference(P< 0 .01) ,the tumors had the lighter weight .Conclusion Chinese caterpillar fungus water decoction has tumor suppression effect on tumor burdened mice .%目的：研究冬虫夏草水煎剂联合顺铂对荷瘤小鼠的抑瘤作用。方法对预先接种结肠癌细胞株 HCT8的荷瘤小鼠分5组，每组10只，其中3组冬虫夏草水煎剂联合顺铂灌胃于荷瘤小鼠（冬虫夏草水剂量为2．5、5．0、10 g/kg ），每天1次，连用12 d；另外，1组给予生理盐水灌胃（空白对照组）；1组给予顺铂灌胃（阴性对照组）。测定应用不同浓度的冬虫夏草水煎剂灌胃，观察荷瘤小鼠瘤体质量的变化。结果对冬虫夏草水煎剂各剂量组的平均瘤体质量与生理盐水组相比差异有统计学意义（P＜0．01），且冬虫夏草水煎剂2．5、5．0g/kg组和顺铂组小鼠的瘤体质量比较，瘤体质量减轻，差异有统计学意义（P＜0．01）。结论冬虫夏草水煎剂对荷瘤小鼠具有一定的辅助抑瘤作用。