云南高原地区成人健康体检人群中幽门螺杆菌感染流行病学调查及相关因素分析

摘要

目的 探讨云南高原地区成人健康体检人群中幽门螺杆菌的感染状况及相关因素,为现阶段幽门螺杆茵感染提供防治依据.方法 应用流行病学调查方法收集2013年1月至2015年2月成人健康体检资料完整人群资料,该资料包括采用全国统一问卷调查和13C-尿素呼气试验检测幽门螺杆菌结果.问卷内容有基本情况、社会经济状况、个人及家庭健康状况情况(包括是否惠消化疾病或症状)、饮食习惯等.结果 共纳入符合条件研究对象1 680例,幽门螺杆菌总感染率为33.5％,男、女幽门螺杆菌感染率分别是33.2％、34.5％,差异无统计学意义(P＞0.05).幽门螺杆菌感染率年龄高峰段40～49岁,为36.7％,但各年龄段间差异无统计学意义(P＞0.05).单因素分析显示幽门螺杆菌感染与民族、常住地、职业、文化程度、婚姻状况、共同生活成员数量无相关性;与个体或家人有无消化系统疾病或症状无相关性;有无饭前洗手与便后洗手、工作生活与学习压力、主要使用的厕所类型、作息时间、共用餐具、饮食习惯、刷牙频率、饮用本来源对幽门螺杆菌感染无影响;有无吸烟、经常接触动物也无影响;幽门螺杆菌感染与社会经济状况、日常交通工具及饮酒有显著相关性.多因素非条件Logistic回归分析结果显示幽门螺杆菌感染与家庭人均月收入呈负相关,其OR值为0.848(OR 95％ CI 0.759～0.949).结论 云南高原地区成人健康体检人群中幽门螺杆菌总感染率低于我国人群自然感染率,应重点关注中年人群和低经济收入人群.%Objective To survey the infection status and related factors of Helicobacter pylori(H.pylori) among adult population receiving physical examination in Yunnan plateau area so as to provide a basis for control and treatment of H.pylori infection at the present stage.Methods The epidemiological survey method was applied to collect the intact data on adult health physical examination from Jan.2013 to Feb.2015,including the results of survey by adopting the unified national questionnaire and 13 C-urea breathe test for detecting H.pylori.The guestionniare contents had the basic conditions,socid economy stalus,personal and family health status cinecluding whether sufferring from digestive diseases or symptoms,dietary habit,etc.Results A tatae of 1 680 eligi ble subjects were included in this study.The total infection rate of H.pylori was 33.5％,which of male and female were 33.2％ and 34.5 ％ respectively,the difference was not statistically significant (P＞0.05).The peak of H.pylori infection rate was in the age group 40-49 years(36.7 ％),but the difference among different age groups had no statistical significance(P＞0.05).The univariate analysis indicated that H.pylori infection was not correlated with nationality,permanent residence,occupation,education level,marital status and number of living together members(P＞0.05);H.pylori infection had no correlation with whether the individual or family members having digestive system disease or symptoms(P＞0.05);washing hands before meals and after defecation,stress of work,living and study,mainly used latrine type,daily means of transportation,work and rest time,sharing cutlery,diets habits,brushing teeth frequency per day and source of drinking water had no influence on H.pylori infection(P＞0.05),and smoking,alcohol drinking and frequently contacting with animals also had no influence on H.pylori infection(P＞0.05).H.pylori infection was significanly correlated with the social economical status,daily means of transportation and alcohol drinking(P＜0.05).The multiple unconditional Logistic regression analysis results indicated that there was negative correlation between H.pylori infection and monthly income,the OR (95％CI)value was 0.848(0.759-0.949).Conclusion The H.pylori total infection rate in adult population receiving physical examination in Yunnan plateau area is lower than the national population natural infection rate.It should focus on middle-aged population and low-income people.