Aim To investigate whether the polymorphisms of exon 16 -3 c/tinSUR1 and E23 K in KCNJ1 are correlated with secondary failure of sulfonylurea in type 2 diabetes mellitus. Methods The association of two SNPs in SUR1 and KCNJ11 was studied by genoty-ping them with ABI SNaPshot Multiplex System in 114 patients with sulfonylurea effective, and 86 patients with secondary failure of sulfonylurea. Results The genotype frequencies distribution of KCNJ11 E23K were found to show no significant differences between SU failure group and SU effective group ( P > 0. 05 ). There were significant differences in the distributive frequency of the SUR1 16-3 c/t polymorphism between SU failure group and SU effective group ( P 0.05);SUR1 16-3c/t各基因型的分布在SFS组和有效组之间差异有统计学意义(P<0.01),且"t"等位基因的频率在SFS组明显增高[比值比(OR)=1.87,95%可信区间(CI)为1.23~2.85,P<0.01].Logistic回归分析中,校正性别、年龄、BMI、F-C肽、TG、TC、HDL-C、LDL-C后,SUR1 16-3c/t 的t/t基因型是SFS发生的独立危险因素[比值比(OR)=2.82,95%可信区间(CI)为1.57～5.07,P＜0.01].结论 SUR1外显子 16-3c/t多态性可能与山东地区磺脲类药物继发性失效有明显相关性.
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