茵栀黄颗粒、双歧杆菌四联活菌片及苯巴比妥片联合蓝光照射治疗早期新生儿黄疸疗效观察

摘要

Objective To observe the clinical effect of Yinzhihuang granules,Bifidobacterium tetravaccine tablets and Phenobarbital pills combined with blue light therapy on early neonatal jaundice.Methods Totally 1 92 cases of neonates were randomly divided into 3 groups:group A was given Yinzhihuang granules and Bifidobacterium tetravaccine tablets;group B was added Phenobarbital pills on the basis of group A;group C was given blue light therapy on the basis of group B.The treatment lasted for 5~7 d.Observe the percu-taneous bilirubin value changes after treatment.Results Comparing the value before and 1 ~ 3 days after treatment in the three groups,the difference was of no statistical significance(P >0.05).The difference had statistical significance at 4~7 days after treatment(P <0.05):group C was much lower than group A and B (P <0.01);group B was significantly lower than group A(P <0.05 ).The total effective rate was 98.4%(63/64)in group C,significantly higher than group A(76.6%,49/64)and group B(81.2%,5 1/64),the difference being statistical(P <0.01 7).The total effective rate was not statistically different between group A and B(P >0.01 7).No adverse reactions occurred in the 3 groups.Conclusion Early combination use of Yinzhihuang granules,Bifidobacterium tetravaccine tablets,Phenobarbital pills and blue light therapy has good curative effect in the treatment of neonatal jaundice.%目的：观察茵栀黄颗粒、双歧杆菌四联活菌片及苯巴比妥片联合蓝光照射治疗早期新生儿黄疸的临床效果。方法2014年1月至12月解放军第四〇四医院儿科收治新生儿黄疸患儿192例，随机分为二联疗法组、三联疗法组、四联疗法组各64例。二联疗法组给予口服茵栀黄颗粒和双歧杆菌四联活菌片；三联疗法组在二联疗法组基础上给予口服苯巴比妥片；四联疗法组在三联疗法组基础上联合蓝光照射治疗。3组各治疗5~7 d，观察治疗后7 d 经皮胆红素值的变化。结果3组患儿治疗前、治疗第1~3天经皮胆红素水平比较，差异无统计学意义(P >0.05)。3组患儿治疗第4~7天经皮胆红素水平比较，差异有统计学意义(P <0.05)，其中四联疗法组经皮胆红素水平较二联疗法组、三联疗法组显著减低，差异有统计学意义(P <0.01)，三联疗法组经皮胆红素水平较二联疗法组显著减低，差异有统计学意义(P <0.05)。四联疗法组总有效率为98.4%(63／64)，显著高于二联疗法组76.6%(49／64)和三联疗法组81.2%(51／64)，差异有统计学意义(P <0.017)，二联疗法组和三联疗法组总有效率比较差异无统计学意义(P >0.017)。3组均未发生不良反应。结论早期联合使用茵栀黄颗粒、双歧杆菌四联活菌片、苯巴比妥配合蓝光照射治疗新生儿黄疸疗效肯定。