Partition of Chiral pharmaceutical intermediate R(-)-Mandelic Acid in Aqueous Two-Phase System of Poly(ethylene glycol)-Ammonium Sulfate

摘要

An aqueous two-phase system of poly (ethylene glycol)-ammonium sulfate was employed to separate R (-)-mandelic acid.The result showed that R (-)-mandelic acid has priority to partition in PEG-rich top phase. This indicated that aqueous two-phase is a very suitable system for separation of R(-)-mandelic acid.