Pregnancy・lnduced Hemophagocytic Lymphohistiocytosis: A Case Report and Literature Review

摘要

Hemophagocytic lymphohistiocytosis(HLH)is a rare but devastating disease characterized by dysregulated immune response and hyp er inflammation.To our knowledge,pregnancy-induced HLH has been rarely reported in the literature.A 30-year・old pregnant woman presented persistent fever for 21 days since 17 weeks of pregnancy.The possible etiologies such as infection,autoimmune disorder,and malignancy had been ruled out based on a series of exhaustive examinations.The disease progressed despite the use of broadspectrum antibiotics and dexamethasone.The patient was diagnosed as pregnancy-induced HLH,and finally recovered completely after termination of pregnancy by caesarean and the continuous use of glucocorticoid which played a crucial part in controlling hyp er inflammation.Pregnancy-induced HLH could be fatal if effective treatment was not initiated timely.Further studies are needed to improve early diagnosis and etiology identification of HLH.