＜正＞ Background Severe burn-blast combined injury is a great challenge to medical teams for its high mortality.The aim ofthis study was to elucidate the clinical characteristics of the injury and to present our clinical experiences on the treatmentof such cases.Methods Five patients with severe burn-blast combined injuries were admitted to our hospital 77 hours post-injury onJune 7,2005.The burn extent ranged from 80% to 97%（89.6%±7.2%）of TBSA（full-thickness burns 75%-92%（83.4%±7.3%））.All the patients were diagnosed as having blast injury and moderate or severe inhalation injury.Functionsof the heart,liver,kidney,lung,pancreas and coagulation were observed.Autopsy samples of the heart,liver,and lungswere taken from the deceased.Comprehensive measures were taken during the treatment,including protection of organdys function,use of antibiotics,early anticoagulant treatment,early closure of burn wounds,etc.All the data wereanalyzed statistically with t test.Results One patient died of septic shock 23 hours after admission（four days after injury）,the others survived.Dysfunction of the heart,liver,lungs,pancreas,and coagulation were found in all the patients on admission,and thefunctions were ameliorated after appropriate treatments.Conclusions Burn-blast combined injury may cause multiple organ dysfunctions,especially coagulopathy.Properjudgment of patients’ condition,energetic anticoagulant treatment,early closure of burn wounds,rational use ofantibiotics,nutritional support,intensive insulin treatment,timely and effective support and protection of organ functionare the most important contributory factors in successful treatment of burn-blast combined injuries.
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