新型AMPA受体非竞争性拮抗剂的合成

摘要

A novel non-competitive AMPA receptor antagonist, １- (3-chlorophenyl) -7,8-dimethoxy3,5-dihydro-benzo[ d] [ 1,2 ] diazepin4-one, was synthesized by a three-step reaction of 3,4-dimethoxy-phenylacetic acid with 3-chloro-benzoic acid in total yield of 36.9％. The structure was characterized by 1H NMR and MS.%以3,4-二甲氧基苯乙酸和间氯苯甲酸为原料.经过3步反应合成了新型AMPA受体非竞争性拈抗剂--1-(3-氯苯基)-7,8-二甲氧基-3,5-二氢-2,3-苯并二氮杂<艹卓>-4-酮,总收率36.9%,其结构经< '1>H NMR和MS表征.