姜烯衍生物的合成及其与吲哚类化合物的Friedel-Crafts反应

摘要

以芳基甲醛和异丙叉丙酮为原料经羟醛缩合反应合成了姜烯(2a)及其一系列衍生物(2b ～2h)；2a ～2f与吲哚类化合物经Friedel-Crafts反应合成了18个新型的含姜烯骨架和吲哚骨架的拼接衍生物,其结构经1H NMR和13C NMR表征.%Zingiberene(2a) and its derivatives(2b ～ 2h) were prepared by Aldol condensation reaction of benzaldehyde derivatives with mesityl oxide.Eighteen novel splicing derivatives with zingiberene and indole skeleton were synthesized by Friedel-Crafts reaction of 2a ～ 2f with the indole derivatives.The structures were characterized by 1H NMR and 13C NMR.