2-{(2'-氰基联苯基-4-基)甲基氨基}-3-硝基苯甲酸甲酯的合成

摘要

以3-硝基-2-氨基苯甲酸甲酯为原料,经三氟乙酰化、N-烷基化和脱保护反应制得坎地沙坦中间体2-{[(2'-氰基联苯基-4-基)甲基]氨基}-3-硝基苯甲酸甲酯,其结构经1H NMR,13C NMR和MS (ESI)确证.%Methyl 2-((2'-cyanobipheny-4-yl) methyl) amino)-3-nitrobenzoate,the key intermediate of Candesartan,was synthesized by trifluoroacetylation,N-alkylation,and deprotection from 2-amino-3-nitrobenzoate.The structure was confirmed by 1 H NMR,13C NMR and MS(ESI).