Distribution and accumulation of Nd, and its effect on secretion of progesterone in mice were studied using radioisotope tracer ((（）147Nd)) technique. Following single intraperitoneal administration of neodymium traced with (（）147Nd) at a dose of 200 mg·kg-1, uneven distribution of the radioactive Nd occurred in various tissues and organs. Much amount of (（）147Nd) accumulates in the bone, and the residue increases with the lapse of time. Some amount of radioactivity was also detected in eyes, blood and brain, but the accumulation decreased with the time due to excretion and re-distribution in mice. In comparison with controls, concentration of progesterone is found to be significantly lower in the serum of administered mice, indicating a significantly inhibitory effect of Nd on secretion of progesterone.
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