血管紧张素转换酶基因插入/缺失多态性与过敏性紫瘢及紫瘢性肾炎相关性研究Meta分析

摘要

Objective To investigate whether there is an association between angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and Henoch-Schonlein Purpura (HSP) as well as Henoch Schonlein Purpura Nephritis (HSPN). Methods (1) A computerized literature search from PubMed, CNKI and Wanfang database was conducted from the early establishment to March 1st 2011, and all the related articles were collected. All the data were analyzed by Stata 11.0. The pooled value of the odds ratios (OR) and 95% confidence interval (95%CI) for D/I were calculated. The pooled statistics were calculated by using the fixed effect model if P value of heterogeneity test was more than 0.1 .otherwise a random effect model was used. Results Five articles were indemnified for the analysis of relation between ACE I/D polymorphism and HSP risk, and also five articles were included for analysis of HSPN . By conducting a meta-analysis we found that there was a positive association between D allele and HSP/HSPN (OR = 1,23,95% CI: 1.04-1.46, P = 0.015; OR = 1.49, 95%CI: 1.01-2.19, P < 0.001). Conclusion ACE gene I/D polymorphism is associated with HSP risk and HSPN risk.%目的 探讨血管紧张素转换酶(ACE)基因插入(I)/缺失(D)多态性与过敏性紫A(HSP)及紫瘢性肾炎(HSPN)的关系.方法 检索PubMed、中国期刊全文数据库和万方数据库,时间从该数据库建立至2011-03-01.收集有关HSP/HSPN ACE I/D多态性的文献,根据文献纳入标准提取相关数据.应用Stata 11.0软件进行Meta分析,计数资料采用优势比(OR)及95%Cl表示,对病例组、对照组I/D进行分析.各组中研究异质性无统计学意义(P≥0.1)时采用固定效应模式,否则采用随机模式分析.结果 纳入针对HSP及HSPN研究的文献各5篇,通过对纳入的文献进行Meta分析发现,D等位基因与HSP易感性相关(OR = 1.23,95% Cl:1.04～1.46,P =0.001),并且与HSPN也存在相关(OR=1.49,95%Cl:1.01～2.19,P<0.001).结论 ACE基因I/D多态性与HSP/HSPN发病关系密切.