Objective To study the impact of fatigue ,cognitive impairment ,depression and anxiety in the life quality of MS patients at early stage. Methods 45 MS patients were selected as research group and 30 healthy check‐ups were selected as control group. The life quality of MS patients was clinically evaluated through the Revised Fatigue Impact Scale ,Mini‐Mental State Examination ,Rey‐Auditory‐Verbal Learning Test ,Simple Rey‐Osterrieth Complex Figure Test ,SDM T ,Stroop Test , Clock Drawing Test ,Hamilton Anxiety Scale and Hamilton Depression Scale. Results The scores of physical functioning ,role limitations due to physical health ,role limitations due to emotions ,pains ,emotional status ,energy ,awareness of health ,so‐cial function ,cognitive function ,health/pressure ,changes of health of research group were significantly lower than those of control group (P< 0.05) ;compared with control group ,the research group had lower scores of short‐term memory and long‐term memory ,lower SDM T scores and longer response time of Stroop test ( P < 0.05) ;the research group had the higher scores on the fatigue (P< 0.05) ;the fatigue was correlated with physical functioning ,role limitations due to physical health , role limitations due to emotions ,pains ,emotional status ,energy ,awareness of health ,social function ,cognitive function , health/pressure and overall quality of life (P< 0.05).Conclusion The life quality of MS patients at early stage is greatly re‐duced with the damages of memory function ,executive function and information processing speed as well as the symptoms of anxiety ,depression and fatigue. The simple factor of fatigue has an impact in the life quality.%目的：探讨多发性硬化（multiple sclerosis ，MS）早期患者疲劳、认知功能障碍、抑郁和焦虑对生活质量的影响。方法临床纳入 MS 患者45例（研究组），同时纳入30例健康者作对照（对照组）。分别采用修订疲劳影响量表、简易精神状态检查量表、Rey 听觉词语学测验、简化 Rey 复杂图形、符号‐数字模式测验（symbol digit modalities test ，SDM T ）、Stroop 测验、画钟试验、汉密尔顿焦虑量表、汉密尔顿抑郁量表及多发性硬化生活质量量表进行临床测评。结果研究组躯体功能、躯体致角色受限、情绪致角色受限、疼痛、情绪状况、精力、健康认识、社会功能、认知功能、健康压力、健康变化评分均明显低于对照组，差异有统计学意义（P＜0.05）；研究组较对照组短延迟记忆与长延迟记忆的成绩降低；SDM T 测验成绩下降，Stroop 测验反应时间长，差异均有统计学意义（P＜0.05）。另外，研究组疲劳得分较高（P＜0.05）。疲劳与生活质量中的躯体功能、躯体问题导致角色受限、情绪问题导致的角色受限、情绪状况、精力、健康认识、认知功能、健康压力、总体生活质量相关（P ＜0.05）。结论 MS 患者早期生活质量即明显降低。虽然早期即出现记忆功能、执行功能／信息处理速度损害及焦虑、抑郁、疲劳症状，但仅疲劳对生活质量造成影响。
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