血管内支架置入术对无症状重度颈动脉狭窄患者认知功能的影响

摘要

目的探讨血管内支架置入术对无症状重度颈动脉狭窄患者认知功能的影响。方法无症状重度颈动脉狭窄患者60例。按照患者及家属意愿，同意在常规内科治疗基础上接受血管内支架置入术为观察组，接受常规内科治疗的为对照组，每组30例。对比2组患者治疗半年后的颈动脉狭窄率，并用简易精神状态量表（MMSE）和蒙特利尔认知评估量表（Mo-CA）评价2组患者认知功能。结果2组患者治疗前颈动脉狭窄率无显著差异，治疗后观察组狭窄率（21.2±3.1）％，明显低于对照组的（59.5±5.4）％；2组患者治疗前MMSE评分无显著差异，治疗后观察组MMSE评分（26.54±4.20）分，明显优于对照组的（21.21±3.51）分；2组患者治疗前MoCA评分无显著差异，治疗后观察组MoCA评分（21.9±3.8）分，明显优于对照组的（17.1±4.5）分，差异均有统计学意义（P＜0.05）。结论血管内支架置入术对无症状重度颈动脉狭窄患者有很显著的效果，有利于减少颈动脉的狭窄率，改善患者认知功能，值得推广。%Objective To explore the effect of intravascular stent angioplasty on cognitive function in asymptomatic pa-tients with severe carotid stenosis.Methods 60 patients with asymptomatic severe carotid stenosis were selected. The patients received routine treatment as control group ,patients received treatment of intravascular stent angioplasty based on control group as observation group ,30 cases in each group. Stenosis rate and cognitive function of two groups were compared by Mini-mental state examination (MMSE) and MoCA.Results Before treatment ,the rate of carotid artery stenosis ,MoCA scores and MMSE scores in two groups showed no significant differences. After treatment ,stenosis rate of observation group with (21.2 ± 3.1)% was significantly lower than (59.5 ± 5.4)% in the control group;MMSE scores with (26.54 ± 4.20) and MoCA scores with (21.9 ± 3.8) scores in observation group were significantly better than (21.21 ± 3.51) and (17.1 ± 4.5) scores in the control group (P< 0.05).Conclusion Intravascular stent angioplasty has a significant effect on cognitive function in a-symptomatic patients with severe carotid stenosis ,which can help to reduce stenosis rate and improve the cognitive function of patients. It is worthy of promotion.