Objective To report application of gene chip in etiological diagnosis in patients with hearing loss. Methods Patients (n=26) with confirmed sensorineural hearing loss were identified to receive DNA microarray tests to determine the etiopathogenisis of their hearing loss. Results Positive rate was 40.00 % in the 10 cases of congenital deafness, 23.08% in the 13 cases of adult sensorineural deafness and in 66.67% in the 5 cases of sudden sensorineural deafness. Conclusion Testing of nine deafness gene mutation using the DNA microarray helps identify the etiology of deafness in patients with hearing loss and worth broad utilization in clinic.%目的 使用耳聋基因芯片技术对耳科门诊耳聋患者进行病因诊断.方法 收集26例明确为感音神经性听力下降的聋病患者,使用基因芯片检测试剂盒进行检测.结果 26例患者中先天性耳聋者10例,检出率为40.00％;成年感音神经性耳聋者13例,检出率为23.08％;突发性耳聋者3例,检出率为66.67％.结论 遗传性耳聋基因检测试剂盒对于明确聋病患者致聋原因有一定的帮助,具有临床推广价值.
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