单味中药对膝骨性关节炎软骨细胞凋亡的作用述略

摘要

Objective To summarize articles about the mechanism of traditional Chinese drug on chondrocyte apoptosis of knee osteoarthritis ( KOA) using a single herb. Methods All the Chinese and English research articles about the effect of single traditional Chinese herb on chondrocyte apoptosis of knee osteoarthritis from China national knowledge internet ( CNKI ) , Vip Database, and PubMed database from 1990 to 2015 were searched. Articles from influential journals, with Chinese herbs representative in clinic, and typical and with a large amount of targeted research were chosen. The selected articles were classified, summarized, and analyzed. Results A lot of articles about mechanism of the use of single Chinese drug on chondrocytes have been published. Most domestic studies based on traditional Chinese medicine ( TCM) theory and focused on clinical efficacy. The studies were weak of TCM knowledge. They pulled out herbs from TCM and focused on the main effective components and the targets in chondrocytes. Therefore the studies were more in the mechanism, among which the clinical effect of TCM on KOA was the inhibition of chondrocyte apoptosis. Conclusion On the whole, both national and international studies acknowledge the efficacy of traditional Chinese drugs on OA. Most studies show that traditional Chinese drug can inhibit chondrocyte apoptosis, promote chondrocyte proliferation, and repair cartilage injury.%目的：粗略汇总单味中药对膝骨性关节炎软骨细胞凋亡的文献，探究单味中药其作用机理。方法检索1990年至2015年期间CNKI，维普，pubmed数据库上有关单味中药对膝骨性关节炎软骨细胞凋亡的国内外中英文文献，从中筛选出所发表期刊具有影响力的、所选中药临床常用并具有代表性的、研究量大且具有针对性的文献，将筛选出的文献进行分类，总结提炼出核心结论并进行分析。结果国内外已经存在大量研究单味中药作用于软骨细胞机制的文献。国内文献多根据中医对本病的认识，辨证虚实，对应中药性味施治，集中研究单味中药的临床疗效研究。国外的中医理论知识薄弱，将中药抽离中医基础，更关注中药内主要有效成分，注重有效成分在软骨细胞中的作用靶点，故对其机理研究较多。其中大部分中药的治疗作用与调节软骨细胞的凋亡密切相关。结论总体上，国内外承认中药对本病的有效作用，大量研究认为中药能够抑制软骨细胞的凋亡，对软骨细胞的增殖有促进作用，可以通过不同途径改善软骨损伤。