针灸治疗绝经后骨质疏松症的实验研究进展

摘要

On the basis of experiments in vivo and in vitro, experimental research progress in acupuncture and moxibustion treatment on postmenopausal osteoporosis from 2004 to 2014 is reviewed. The bone mineral density, bone histomorphometry, bone biomechanics, bone metabolism, serum estrogen and cytokine are summarized respectively from in vivo experiments, and each index is listed in a chronological order. Acupuncture points, treatment methods, measured indexes and results of the literatures are introduced. From in vitro experiments, experimental research progress in the effect of conditioned serum after acupuncture on the number, bone resorption function and apoptosis of rat osteoclasts is summarized. Based on these, the problems of current researches are pointed out. The problems include the difference of the animal model, the variety of selection of the acupuncture points, and the unknown mechanism of acupuncture and moxibustion treatment on postmenopausal osteoporosis. At last, the research ideas of next step are proposed, in order to offer the reference for related researchers.%以在体实验与离体实验作为文献的基本分类标准，进一步以各项实验室检测指标作为细化分类，分别对自2004年至2014年近11年来针灸治疗绝经后骨质疏松症作用的实验研究进行了由浅入深的分类综述。在体实验方面，分别从骨密度、骨组织形态学及骨生物力学、骨代谢生化指标、血清雌激素及细胞因子等方面进行了阐述，每个指标所属文献按时间先后顺序列出，每条文献详细介绍了动物分组、针灸选穴及治疗方法、检测指标及结果等；离体实验方面，整理总结了关于针刺血清对大鼠破骨细胞数量、骨吸收功能及其凋亡影响的实验研究进展。在此基础上作出评价，指出目前研究尚存在的问题，主要包括大鼠模型的差异、针灸取穴施术的多变，以及针灸治疗绝经后骨质疏松症作用机理未明等；提出了下一步探究的思路，以期为相关研究者提供借鉴与参考。