持续心理干预对卵巢癌患者生物治疗期间生活质量的影响

摘要

目的：探讨持续心理干预对卵巢癌生物治疗患者负性情绪﹑免疫功能及生存质量的影响。方法2013年11月—2014年9月将符合入选条件的80例卵巢癌患者,按随机数字表法随机分为对照组和观察组,每组40例。对照组采用生物治疗和常规护理,观察组在此基础上给予心理干预。两组于心理干预前和3周末采用汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)及欧洲肿瘤患者生存质量核心问卷(QLQ-C30)对其心理﹑生理及生存质量进行测评,采用流式细胞仪检测患者免疫水平。结果心理干预3周后,观察组 HAMD 评分为(9.27±3.15)分、HAMA 评分为(10.17±3.06)分,对照组HAMD 评分为(16.93±10.49)分、HAMA 评分为(18.97±6.24)分,两组比较差异有统计学意义(t 值分别为1.74,1.78；P <0.05)。观察组的总体健康状况、情感功能、认知功能评分分别为(71.52±19.50),(80.97±15.59),(65.40±19.97)分,均高于对照组,差异有统计学意义(t 值分别为2.45,2.67,2.58；P <0.05)；观察组疲劳、失眠和食欲评分分别为(34.76±20.78),(41.75±29.19),(59.57±15.78)分,均低于对照组,差异有统计学意义(t 值分别为2.98,3.27,2.88；P <0.05)。持续心理干预对患者免疫治疗疗效无明显影响。结论持续心理干预可以改善卵巢癌患者负性情绪,提高生活质量,在辅助肿瘤生物治疗过程中有一定积极作用。%Objective To explore the effect of persistent psychological intervention on negative emotions, immune function and quality of life to patients with ovarian cancer in biotherapy period. Methods A total of 80 ovarian cancer patients were randomly divided into the control group (biotherapy and routine nursing) and the intervention group ( psychological intervention in addition to biotherapy and routine nursing). In the intervention group, Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD), and European organization for research and treatment of cancer quality of life questionnaire-30 ( QLQ-C30) were used to measure the psychosomatic reaction, quality of life, and immune level by flow cytometry among ovarian cancer patients during biotherapy 3 weeks after and before psychological interventions. Results Three weeks after intervention, the scores of HAMD (9. 27 ± 3. 15) and HAMA (10. 17 ± 3. 06) in the intervention group were significantly lower than those in control group (16. 93 ± 10. 49) and (18. 97 ± 6. 24) (t = 1. 74,1. 78;P <0. 05), while the scores for general quality of life (71. 52 ±19. 50), the cognitive function (65. 40 ±19. 97) and emotional function (80. 97 ±15. 59) in the intervention group were higher than than these of the control group (t =2.45,2. 67,2. 58;P < 0. 05). The scores for fatigue (34. 76 ± 20. 78), insomnia (41. 75 ± 29. 19) and loss of appetite (59. 57 ± 15. 78) in the intervention group were lower than that of the control group with statistically significant differences (t = 2. 98,3. 27,2. 88;P < 0. 05). Persistent psychological intervention had no significant effect on the immune level of patients ( P > 0. 05). Conclusions Persistent psychological intervention can improve the state of negative emotions and quality of life, and has positive effects on assisting cancer biotherapy.