Objective: To investigate the relationship between the monoamine neurotransmitters and cerebral cardiac stroke after photochemical reaction. Method: An animal model of photochemically induced thrombotic focal ischemia in tree shrews were produced by radiating the right skull. The measurements of monoamine neurotransmitters in cortex and plasma and of brain water contents were performed. Results: Norpinephrine(NE), dopamine(DA), and serotonine(5 HT) decreased markedly, but 5 hydroxyindole 3 acetic(5 HIAA) acid increased gradually with the ischemic time( P < 0.01 ). The brain water content was higher than that of the control( P < 0.01 ). Moreover, plasma NE increased during 24 hours but decreased at 72 hours after photochemical reaction( P < 0.01 ). Conclusion: The monoamine neurotransmitters could enhance cerebral vascular permeability, promote the formation of brain edema and contribute to the pathogenesis of cerebral carding stroke after cerebral ischemia.
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