Objective To evaluate the clinical effect and toxicity of gemcitabine combined with cisplatin in the treatment of elder advanced non-small cell lung cancer(NSCLC). Method The 336 cases of elder patients with advanced non-small cell lung cancer were randomly assigned to six group, and 56 patients per group. The group A was treated with high doses of gimcitabine (1000mg/m2, dl); the group B was treated with high doses of cisplatin (75mg/m2, dl); the group C was treated with low doses of gemcitabine (500mg/m2, dl) combined with low doses of cisplatin (38mg/m2, dl); the group D was treated with low doses of gemcitabine (500mg/m2, dl) combined with high doses of cisplatin (75mg/m2, dl); the group E was treated with high doses of cisplatin (75mg/m2, dl) combined with low doses of cisplatin (38mg/m2, dl); the group F was treated with high doses of cisplatin (75mg/m2, dl) combined with high doses of cisplatin (75mg/m2, dl), 3 weeks for 1 cycle per group. Result The immune function, efficacy, quality of life(QOL) and one-year survival rate of group C were significant improvement compare with other groups, and untoward effects were significantly lowered than others. Conclusion This suggests that the combination of gemcitabine and cisplatin chemotherapy can indeed improve the effect of the treatment of senile non-small cell lung cancer, and combination at the same time reduce the use of two drugs doses to achieve the best therapeutic effect.%目的 探讨吉西他滨和顺铂联合化疗用于中老年晚期非小细胞肺癌的临床疗效.方法 选取2015年3月至2016年6月本院收治的中老年晚期非小细胞肺癌患者336例,年龄50~80岁,随机分为A~F 6组,每组各56例.A组患者单独给予高剂量吉西他滨(1000mg/m2,dl);B组患者单独给予高剂量顺铂(75mg/m2,dl);C组联合给予低剂量吉西他滨(500mg/m2,dl)和低剂量顺铂(38mg/m2,dl);D组联合给予低剂量吉西他滨(500mg/m2,dl)和高剂量顺铂(75mg/m2,dl);E组联合给予高剂量吉西他滨(1000mg/m2,dl)和低剂量顺铂(38mg/m2,dl);F组联合给予高剂量吉西他滨(1000mg/m2,dl)和高剂量顺铂(75mg/m2,dl).每组治疗周期均为每三周一次.观察各组的治疗效果及不良反应发生情况.结果 低剂量吉西他滨联合低剂量顺铂化疗组(C组)患者治疗后的疗效及生存率均较吉西他滨或顺铂单独给药组以及其他处理组有显著改善且不良反应显著低于其他组.结论 低剂量的吉西他滨联合低剂量顺铂对中老年非小细胞肺癌有更好的治疗效果.两种药物联合使用时,单独增加其中在一种化疗药物的剂量均会引起诸多不良反应,且对于患者的术后生活质量以及存活率无明显改善作用.
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