阿尔茨海默病与轻度认知障碍患者的头颅CT对比观察

摘要

目的 对比观察阿尔茨海默病(Alzheimer disease,AD)、轻度认知障碍(mild cognitive impairment,MCI)及健康老年人头颅CT影像学表现的差异.方法 选取2012年1月至2017年8月在浙江省宁波市镇海区人民医院和宁波市第二医院就诊的AD患者(AD组)、MCI患者(MCI组)及健康体检老年人(对照组)各80例,均采用西门子64排双源CT机进行头颅扫描,电压120kV,电流380mAs,扫描层厚5mm,层间距5mm.观察比较各组患者的CT测量参数,包括外侧裂宽度、额角指数、尾状核头间径、第三脑室宽度、脑沟宽度、大脑纵裂宽度等.结果 与AD组比较,MCI组患者额角指数、尾状核头间径明显增高,第三脑室宽度、脑沟宽度、大脑纵裂宽度明显降低,差异有显著性(P＜0.05);与对照组比较,MCI组患者外侧裂宽度、第三脑室宽度、大脑纵裂宽度均明显增高,额角指数明显降低,差异有显著性(P＜0.05).结论 头颅CT参数测量为MCI的临床诊治提供了客观依据,有利于进一步治疗及预防AD的发生.%Objective Compare and observe the difference of Alzheimer disease patients, mild cognitive impairment and healthy old men. Method From January 2012 to August 2017, 80 cases of AD patients(AD group), MCI patients(MCI group) and healthy medical examination elderly people(control group) were selected at the Zhenhai District People's Hospital and the second Hospital of Ningbo, Zhejiang Province. All of them used Siemens 64 pairs of dual-source CT machines for skull scanning with a voltage of 120 kV. Current 380mAs, scanning layer thickness 5mm, layer spacing 5mm. Observed and compared the CT measured parameters, including lateral fissure width, frontal angle index, caudatum nucleus, third ventricle width, sulus width and longitudinal diastema width. Result AD group compared with MCI group, the frontal angle index, caudatum nucleus, third ventricle width, sulus width and longitudinal diastema width had obvious difference (P＜0.05). MCI group compared with control group, the lateral fissure width, frontal angle index, third ventricle width, sulus width and longitudinal diastema width had obvious difference (P＜0.05). Conclusion The CT measured parameters of MCI patients can provide objective basis for clinical diagnosis and treatment. It is beneficial to treatment and prevention of AD.