神经节苷脂治疗36例急性重症颅脑损伤患者的疗效分析

摘要

Objective:To investigate the clinical value of the ganglioside in acute severe traumatic brain injury.Methods:71 patients with severe traumatic brain injury were divided into two groups,on the basis of general treatment,the observation group were treated with gangliosides,the control group were treated with citicoline.Results: (1)The effective rate of the observation group were 83.33% (30/36),significantly higher than control 60.00% (21/35),the difference had statistically significant(P<0.05). 1W after treatment, the MMSE score of two groups had no significant difference (P>0.05).2W and 4W after treatment,The MMSE scores were (24.43±3.28) and (28.56±3.58),significantly higher than the same period of time patients in the control group,the differences had statistically significant (P<0.05).Conclusion:In the treatment of acute severe traumatic brain injury,gangliosides has a good therapeutic effect,can improve cognitive function in patients with high clinical value.%　　目的：探讨神经节苷脂在急性重症颅脑损伤中的临床应用价值.方法：选择重型颅脑损伤患者71例,根据治疗方法的不同分为观察组和对照组.在一般治疗的基础上,观察组患者应用神经节苷脂,对照组患者应用胞磷胆碱.结果：(1)观察组患者治疗有效率为83.33%(30/36),显著高于对照组患者的60.00%(21/35),其差异有统计学意义(P<0.05).(2)治疗后1W,两组MMSE评分间无统计学差异(P>0.05).治疗后2W及4W,观察组患者MMSE评分均值分别为(24.43±3.28)和(28.56±3.58),显著高于同时间段对照组患者评分,其差异均有统计学意义(P<0.05).结论：在急性重症颅脑损伤的治疗中,神经节苷脂有良好的治疗效果,能够显示改善患者认知功能,具有很高的临床应用价值.