ER,PR,Ki67,p53表达与乳腺癌淋巴结转移相关性研究和临床意义

摘要

目的：探讨ER,PR,Ki67及p53表达与乳腺癌淋巴结转移的相关性研究和临床意义。方法：选取我院收治的95例原发性乳腺癌患者,均给予手术治疗,并于术后进行病理检测淋巴结转移情况,同时采用半定量免疫组化测定乳腺癌ER,PR,Ki67及p53的表达情况,最后将这些分子的表达与腋窝淋巴结转移情况进行比较与分析。结果：95例患者中淋巴结转移阳性率为43.16%,ER,PR,Ki67及p53的阳性表达率分别为63.16%,75.79%,71.58%和55.79%；ER,PR,Ki67及p53表达与淋巴结转移不存在直接相关性(P>0.05)。结论：ER,PR,Ki67及p53表达与淋巴结转移不存在直接相关性,两者相互独立而又相互补充,共同影响患者的预后,临床应综合各项因素、准确评估患者的预后。%Objective:To study of the e the correlations between the expressions of ER,PR,Ki67,and p53 in cancer tissue and the lymph note status of patients with breast cancer,and the clinical significance.Methods:86 patients with breast cance were given surgical treatment.The expressions of ER,PR,Ki67,and p53 in cancer tissue and lymph node status were assessed pathologically and by semi-quantitative immunohistochemitry after operation.Finally the correlation between the expression of these molecules and lymph node status were analyzed.Results:Among 95 patients with the positive lymph node metastasis rate was 43.16%,the positive expression rates of ER,PR,Ki67 and p53 were respectively 63.16%,75.79%,71.58%and 55.79%.There was no direct correlation between the expression of ER,PR,Ki67 and p53 and lymph node metastasis (P>0.05).Conclusion:The expression of ER,PR,Ki67 and p53 and lymph node metastasis was no direct correlation.Clinical various factors should be comprehensive,thus accurately assessing the prognosis of patients with breast cancer.