乳腺浸润性导管癌3T磁共振动态增强特征与预后的相关性研究

摘要

目的 研究3T磁共振乳腺浸润性导管癌动态增强表现特征与乳腺癌预后因子ER、PR、Herb-2、Ki-67的相关性.资料与方法 对69例乳腺癌患者术前行动态增强MRI检查,分析其影像特征(病灶形态、边缘、内部增强情况、时间-信号强度曲线)与预后因子ER、PR、Herb-2、Ki-67的相关性.结果 乳腺浸润性导管癌形态特征及内部增强表现与预后因子Ki-67存在相关性(P<0.05),动态增强时间-信号强度曲线与ER存在相关性(P<0.05).结论乳腺浸润性导管癌的动态增强特征与部分预后因子有显著相关性,提示磁共振动态增强检查在一定程度上可以判断肿瘤的预后情况,并有助于临床治疗方案的制定.%Purpose To study the correlation between findings of dynamic contrastenhanced MRI (DCE-MRI) and prognostic factors (ER, PR, Herb-2, and Ki-67) in patients with invasive ductal carcinoma of breast. Materials and Methods DCEMRI was performed in 69 patients with invasive ductal carcinoma of breast before confiemed by biopsy prior surgery. Correlation between MRI features (morphology, enhancement pattern, and time-signal intensity curve) and prognostic factors (ER, PR, Herb-2, and Ki-67) was analyzed with chi-square test. Results The features of mor-phology (lobular and irregular forms) and enhancement (circular reinforcement) were positively correlated with Ki-67 (P ＜ 0.05) and the time-signal intensity curve was positively correlated with ER (P ＜ 0.05). Conclusion DCE-MRI is a useful modality in evaluation of invasive ductal carcinoma of breast. Its positive correlation with Ki-67and ER may provide additional prognostic information for patient management.