腰椎骨髓脂肪含量与年龄、性别、体重指数及腰围的相关性

摘要

目的：通过分析腰椎骨髓脂肪含量与年龄、性别、体重指数（BMI）及腰围的相关性，探讨骨髓脂肪含量的体质特点，以加深对骨质疏松发生规律的认识。资料与方法纳入健康志愿者或慢性腰腿痛患者144例，测量其身高、体重、腰围，并计算BMI。采用单体素点分辨波谱法对L3椎体进行波谱采集，以1.3 ppm波峰为三酰甘油峰，水峰位于4.67 ppm，计算脂水比与脂肪比例。比较不同性别、年龄、BMI、腰围组间L3椎体脂水比、脂肪比例的差异。分析年龄与L3椎体脂水比及脂肪比例的相关性。结果男、女L3椎体脂水比、脂肪比例总平均值比较差异无统计学意义（t=－0.267、－0.993，P>0.05）。不同年龄段患者L3椎体脂水比、脂肪比例的总平均值差异有统计学意义（F=3.723、5.478，P<0.05）。女性61~70岁组L3椎体脂水比、脂肪比例均明显高于20~30岁、31~40岁、41~50岁、51~60岁组（P<0.05），女性L3椎体脂肪比例20~30岁组低于>70岁组（P<0.05）。61~70岁组男女脂水比总平均值均明显高于20~30岁、31~40岁、41~50岁、51~60岁组（P<0.05）。20~30岁组男女脂肪比例总平均值均低于31~40岁、41~50岁、51~60岁、61~70岁、>70岁组（P<0.05），61~70岁组与31~40岁、41~50岁、51~60岁组比较，差异均有统计学意义（P<0.05）。不同BMI及男性和女性不同腰围组间L3椎体脂水比及脂肪比例比较，差异均无统计学意义（P>0.05）。年龄与L3椎体脂肪比例呈正相关（r=0.321， P<0.05）。结论腰椎骨质脂肪含量与患者年龄相关，与性别、BMI、腰围均无关。%PurposeTo investigate the physical characteristics of the lumbar bone marrow fat content by analyzing the correlation of the lumbar bone marrow fat content with age, gender, body mass index (BMI) and waist circumference. It may be helpful to deepen the understanding the occurrence regularity of osteoporosis. Materials and Methods A total of 144 subjects were recruited including both healthy volunteers and the patients with chronic low back pain. The height, weight and waist circumference were measured, and the body mass index was calculated. All the subjects took spectroscopy sequence at the third lumber vertebra with single-voxel point resolved spectroscopy (PRESS) method. Lipid (1.3 ppm) to water (4.67 ppm) ratio (LWR) and lipid fractions (FF%) were measured. LWR and FF% of L3 were compared among the patients with different gender, age, BMI and waist circumference. The correlation of LWR and FF% of L3 and age were analyzed.Results The LWR and FF% of L3 showed no signiifcant difference between the male and female (t=-0.267 and-0.993,P>0.05). There was statistical difference of LWR and FF% among the different age groups (F=3.723 and 5.478,P<0.05). LWR and FF% of female in 61-70 year-old group showed signiifcant higher than that in 20-30, 31-40, 41-50 and 51-60 year-old group (P<0.05). FF% of L3 in 20-30 year-old female group showed signiifcant lower than that in >70 year-old group (P<0.05). LWR of L3 for both male and female in 60-70 year-old group also showed signiifcant higher than that in 20-30, 31-40, 41-50 and 51-60 year-old group (P<0.05). FF% for both male and female in 20-30 year-old group showed signiifcant lower than that in 31-40, 41-50, 51-60, 61-70 and>70 year-old group (P<0.05). FF% of 61-70 year-old group was signiifcant different from that in 31-40, 41-50, 51-60 year-old group (P<0.05). The LWR and FF% of L3 showed no signiifcant difference between the different BMI groups and waist circumference groups (P>0.05). Age was positive correlated with FF% of L3 (r=0.321,P<0.05).Conclusion The lumbar bone marrow fat content is correlated with age, but is not correlated with gender, BMI and waist circumference.