美国甲状腺协会超声分类与细针穿刺细胞学检查诊断良恶性甲状腺结节

摘要

目的 评价美国甲状腺协会(ATA)超声分类与甲状腺细针穿刺(FNA)细胞学检查对良恶性甲状腺结节的诊断价值.方法 回顾性分析342例甲状腺结节患者(共357个结节)的资料.所有患者均于超声检查后接受外科手术或FNA细胞学检查.根据2015年版ATA甲状腺结节诊治指南,对超声图像进行分类评估,并与术后病理结果对照,评价ATA超声分类及FNA细胞学检查的诊断效能.结果 357个甲状腺结节中,248个经术后病理确诊,包括233个恶性结节及15个良性结节.对照病理结果,超声ATA分类诊断甲状腺恶性结节的准确率为88.31％(219/248),敏感度为90.99％(212/233),特异度为46.67％(7/15),阳性预测值为96.36％(212/220),阴性预测值为25.00％(7/28);FNA细胞学检查诊断甲状腺恶性结节的准确率为98.81％(83/84),敏感度为100％ (75/75),特异度为88.89％(8/9),阳性预测值为98.68％(75/76),阴性预测率为100％(8/8).ROC曲线分析显示,2种方法诊断恶性甲状腺结节的曲线下面积(AUC)分别为0.653和0.944(Z=2.397,P=0.017).结论 ATA超声分类方法对鉴别良恶性甲状腺结节具有较高的诊断价值,FNA细胞学检查能更加有效地判断甲状腺结节性质.%Objective To evaluate the efficiency of thyroid ultrasound grading formulated by American Thyroid Association (ATA) and fine-needle aspiration (FNA) biopsy in diagnosing benign and malignant thyroid nodules.Methods A retrospective analysis of 357 thyroid nodules in 342 patients underwent surgical excision or FNA biopsy after thyroid ultrasound was performed.All ultrasonograms were graded according to ATA diagnosis guideline for thyroid nodule versi on 2015.The diagnostic efficiency of ATA grading and FNA biopsy were evaluated comparing with postoperative pathological results.Results There were 248 of 357 thyroid nodules confirmed with postoperative pathology,including 233 malignant and 15 benign nodules.The diagnostic accuracy,sensitivity,specificity,positive and negative predictive value of ATA guideline in diagnosis of malignant thyroid nodules was 88.31％ (219/248),90.99％ (213/233),46.67％ (7/15),96.36％ (212/220)and 25.00％ (7/28),respectively,while of FNA biopsy was 98.81％ (83/84),100％ (75/75),88.89 ％ (8/9),98.68％ (75/76) and 100％ (8/8),respectively.The area under the curve (AUC) of ROC was 0.653 and 0.944 for ATA grading and FNA biopsy,respectively (Z=2.397,P=0.017).Conclusion ATA guideline has high diagnostic value in differential diagnosis of thyroid nodules,while FNA may be more effective in diagnosis of thyroid nodules.