神经精神性狼疮认知功能改变机制及结构和功能MRI研究进展

摘要

Central nervous system involvement in 25%—75% of systemic lupus erythematosus (SLE) patients, especially the brain, can produce a variety of neuropsychiatric symptoms. There is evidence that changes in olfactory and cognitive function may be earlier than the occurrence of neuropsychiatric symptoms, contributing to the early diagnosis of lupus encephalopathy. In recent years, various functional MRI (fMRI) techniques have important value for the diagnosis and evaluation of systemic lupus erythematosus and the occurrence and development of disease. This article reviews the changes in olfactory and cognitive aspects of patients with systemic lupus erythematosus and the application of structural and functional MRI.%25%~75%的系统性红斑狼疮患者中存在中枢神经系统受累,尤其是脑,可产生各种神经精神症状,而且有证据表明嗅觉和认知功能改变可能早于神经精神症状的发生,因此有助于对狼疮脑病的早期诊断.近年来,随着各种功能MRI技术的发展,对系统性红斑狼疮的诊断、评估以及疾病的发生发展有重要价值.作者就系统性红斑狼疮患者在嗅觉和认知方面的改变,以及结构和功能MRI在其中的应用展开综述.