Objective To explore the relationship and signiifcance of adiponectin (ADPN) and leptin (LEP) levels in patients with chronic hepatitis B (CHB). Methods Serum levels of ADPN, LEP, ALT and AST were assayed in 52 patients with CHB, 51 hepatitis B virus (HBV) carriers and 46 normal people. The correlation of liver function injury severity with plasma ADPN and LEP was analyzed. Results HBV carriers group has higher ADPN level than CHB group and the control group (P<0.05), but no signiifcant differences between CHB group and the control group. The serum level of LEP in CHB group is higher than HBV carriers group and the control group (P<0.05), while LEP levels in HBV carriers group and the control group have no signiifcant difference. In these 3 groups, ADPN and LEP levels in women are higher than men (P<0.05). CHB group has higher AST and ALT level compared to HBV carriers group and the control group (P <0.05), but HBV carriers group and the control group have no significant difference. Correlation analysis revealed that LEP level was positively related with ALT and AST level (r=0.386, P<0.05;r=0.751, P<0.05). conclusions ADPN and LEP have close connection with the initiation, progression of CHB. It could be the index to evaluate the severity of the disease.%目的：探讨CHB患者血清脂联素（ADPN）、瘦素（LEP）水平的关系及意义。方法检测52例CHB患者、51例HBV携带者以及46例健康体检者血清中脂联素、瘦素的水平，并测定ALT、AST水平，对脂联素、瘦素和肝功能损伤程度的相关性进行分析。结果HBV携带者组ADPN水平较CHB患者组、对照组高（P ＜0.05），CHB组患者与对照组组间ADPN水平无明显差异。CHB患者组LEP水平较HBV携带者组、对照组高（P ＜0.05）；HBV携带者组与对照组组间LEP水平无明显差异。3组患者的ADPN、LEP水平均呈现出女高男低的现象（P ＜0.05）。CHB组患者AST、ALT水平均较HBV携带者组、对照组显著升高（P＜0.05），HBV携带者组和对照组组间AST、ALT水平无明显差异。LEP水平与ALT和AST呈正相关（r=0.386，P＜0.05；r=0.751，P＜0.05）。结论ADPN、LEP与CHB的发生及发展密切相关，可能是病情轻重的标志。
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