药物洗脱支架与裸金属支架在老年冠状动脉粥样硬化性心脏病患者中有效性和安全性的Meta分析

摘要

目的 采用Meta分析比较老年冠状动脉硬化性心脏病(冠心病)患者植入药物洗脱支架(DES)和裸金属支架(BMS)的有效性和安全性.方法 检索PubMed、Embase、Cochrane Library、中国知网和万方数据库于2017年10月28日前发表关于老年冠心病患者中DES和BMS有效性和安全性的随机对照研究(RCTs)或队列研究(CS).结局为全因死亡(ACM)、心肌梗死(MI)、靶血管再次血运重建(TVR)、心源性死亡(CD)、支架内血栓形成(ST)和出血.合并所有研究数据作为整体效应量,按研究设计行组分析.结果 共纳入17篇文献,含10 813例患者.DES植入患者整体和CS组ACM[相对危险度(RR) ＝0.71、0.68,P均＜0.001]、MI(RR＝0.66,P＜0.001;RR＝0.60,P＝0.008)、TVR(RR＝0.50、0.54,P均＜0.001)、CD(RR＝0.73、0.72,P＝0.003、0.020)和ST(RR＝0.68、0.59,P＝0.02、0.01)风险显著低于BMS植入患者,但出血风险差异无统计学意义(RR＝ 1.00、1.00,P＝0.96、0.97).RCT组中,DES植入患者MI(RR＝0.68,P＝0.003)和TVR(RR＝0.43,P＜0.001)风险较BMS植入患者显著降低,其余结局差异无统计学意义.结论 DES在老年冠心病患者中有效性和安全性均优于BMS.%Objective To evaluate the efficiency and safety of drug-eluting stents (DES) and bare metal stents (BMS) in elderly with coronary artery disease (CAD).Methods PubMed,Embase,Cochrane Library,CNKI and Wanfang databases were searched before October 28,2017.The pertinent randomized controlled trials (RCTs) and cohort studies (CS) were included.The outcomes were all-cause mortality (ACM),myocardial infarction (MI),target vessel revascularization (TVR),cardiac death (CD),stent thrombosis (ST) and bleeding.Relative risk (RR) with 95％ confidence interval (95％CI) was analyzed.Results A total of 17 studies with 10 813 patients were included.Overall and in CS group,there were significant lower risks of ACM (RR＝0.71,0.68,both P＜0.001),MI (RR＝0.66,P＜0.001;RR＝0.60,P＝0.008),TVR (RR＝0.50,0.54,both P＜0.001),CD (RR＝0.73,0.72,P＝0.003,0.020) and ST (RR＝0.68,0.59,P＝ 0.02,0.01) in DES patients compared with BMS patients,but the risk of bleeding was not significantly different (RR ＝ 1.00,1.00,P ＝ 0.96,0.97).In RCT group,DES (compared with BMS) was only associated with significantly lower risks of MI (RR＝0.68,P＝0.003) and TVR (RR＝0.43,P＜0.001),no difference was detected in other indexes.Conclusion DES is more efficacious and safer than BMS for elderly patients with CAD.