原发性胆汁性肝硬化与肝血瘀证

摘要

Objective: To explore the relationship between primary biliary cirrhosis and hepatic stasis syndrome. Methods; According to the standard of hepatic stasis syndrome that we formulate, hepatic stasis syndrome were duided into three types, mild hepatic stasis syndrome, moderate hepatic stasis syndrome and severe blood stasis syndrome. According to the standard , we differentiated was investigated the 84 cases of PBC patients was investigated and 40 normal subjects as control group, investigated the incidence of hepatic stasis syndrome was investigated, and the performance of immune changes between blood stasis syndrome and non-blood stasis syndrome in patients with PBC were studied. Results; Of the 84 cases of PBC patients, cases with hepatic stasis syndrome were 71 (84.5%), in which with mild blood stasis were 22 cases (26.2% ), moderate blood stasis syndrome were 25 cases (29.8%), 24 cases (28.5% ) were severe blood stasis syndrome patients, 13 cases (15.5% ) were non-blood stasis syndrome patients. And this had been further confirmed by pathological diagnosis. The frequency of specific symptoms and signs appeared higher in people with dark purple tongue, sublingual veins face, guns and purple eyes black, the proportion were 59.5% and 57.1%. In the immune parameters of patients with hepatic stasis syndrome and non-blood stasis syndrome, CD4+ , CDS+, CD4V CD8+ , IgG, IgM, IgA, B factors were different from control group, but no significant difference between the two PBC groups (P> 0.05), the indicators of C3 and C4 were not only significantly lower in both PBC groups, but aslo the two groups of PBC were significantly different (P <0.05), hepatic stasis syndrome were more apparently decreased. Conclusion: This study showed that the hepatic stasis syndrome in patients with PBC accounted for 84.5% , and it is closely related with immune dysfunction.%目的:探讨原发性胆汁性肝硬化(PBC)与肝血瘀证的关系.方法:根据我们制定的肝血瘀证辨证标准,将肝血瘀证划分为轻度、中度、重度3型,通过对84例PBC患者进行肝血瘀证辨证,探讨PBC患者肝血瘀证的发生率,且设40例正常人作为对照组,考察PBC肝血瘀证患者与非肝血瘀证患者及正常人的免疫学指标.结果:84例PBC中肝血瘀证患者71例(84.5％),其中轻度22例(26.2％),中度25例(29.8％),重度24例(28.5％)；非肝血瘀证患者13例(15.5％).两组患者具体症状体征出现的频率则以舌质紫暗、舌下静脉曲张以及面部、齿龈及眼周紫黑为高,在84例PBC患者中所占比例分别为59.5％和57.1％.肝血瘀证与非肝血瘀证两组患者的免疫指标CD4+、CD8+、CD4+/CD8+、IgG、IgM、IgA、B因子均异于正常对照组(P＜0.05),但两组之间差异无显著性意义(P＞0.05)；补体C3、C4不仅两组异于正常对照组(P＜0.05),且两PBC组间差异有显著性意义(P＜0.05),肝血瘀证者降低更为明显.结论:研究表明PBC患者中肝血瘀证者占84.5％,且与免疫功能异常密切相关.