Objectives:To compare the implantation rate,pregnancy rate and miscarriage rate following transfer of frozen -thowed embryos on 5 th day and 6 th day,and to assess the predictive value of the re -expansion of the blastocoel in pregnancy outcome.Methods:This retrospective study was done among 21 1 patients received fro-zen -thawed single blastocyst transfer treatment in our productive center from October 201 3 to October 201 4.The patients were divided into 5 th day group (n =1 1 3)and 6 th day group (n =98).The implantation rate,pregnancy rate and miscarriage rate were compared between the two groups.Also the patients were divided into three groups according the re -expansion of the blastocyst:partial expansion group (n =54),complete expansion group (n =1 05),hatch group (n =52).The clinical pregnancy rate,implantation rate and the abortion rate among the three groups were compared.Results:The clinical pregnancy and implantation rate for single blastocyst transferred of 5 th day group were significantly higher than these of 6 th day group (63.72% vs 46.94%,63.72% vs 46.94%,P <0.05).The miscarriage rate of 5 th day group was lower than that of 6 th day group (1 3.89% vs 1 7.39%).The clin-ical pregnancy rate (40.74%)and implantation rate (40.74%)of partial expansion group were significantly lower than the clinical pregnancy rate (60.95%,61 .54%)and implantation rate (60.95%,61 .54%)of complete ex-pansion group and hatch group.Though abortion rate of the three groups decreased successively but no statistical difference was found (1 8.1 8%,1 5.63% and 1 2.50% respectively).Conclusions:Compared with 6 th day blasto-cyst,5 th day blastocysts has better development potential.Frozen -thowed embryos on 5 th day can obtain better pregnancy outcomes.The better the blastocoel re -expansion degree after frozen -thowed is,the higher its growth potential and the better the pregnancy outcome it will have.%目的：分析比较第5天（Day 5）、第6天（Day 6）的冻融单囊胚移植对妊娠结局的影响，探讨不同发育天数囊胚对冻融后胚胎的发育潜能和临床结局的影响，以及囊胚解冻后的扩张程度对临床结局的影响。方法：回顾性分析2012年10月至2014年10月在我院生殖中心行冻融单囊胚移植的患者211例，根据冷冻时间不同分为 Day 5冷冻组（n ＝113）和 Day 6冷冻组（n ＝98），比较两组患者的临床妊娠率，胚胎种植率和早期流产率。根据囊胚解冻后2小时囊腔的扩张程度分为：部分扩张组（n ＝54）、完全扩张组（n ＝105）、孵出组（n ＝52），比较三组患者的临床妊娠率，胚胎种植率，早期流产率。结果：Day 5冷冻组的临床妊娠率（63.72％）和种植率（63.72％）均显著高于 Day 6冷冻组（46.94％，46.94％）（P ＜0.05），Day 5冷冻组的流产率（13.89％）低于 Day 6冷冻组（17.39％）；冻融后部分扩张组的临床妊娠率（40.74％）和种植率（40.74％）均显著低于完全扩张组和孵出组的临床妊娠率（60.95％、61.54％）和种植率（60.95％、61.54％），三组的流产率依次递减但无统计学差异分别为（18.18％、15.63％、12.50％）。结论：Day 5囊胚较 Day 6囊胚具有更好的发育潜能，解冻后可获得更好的妊娠结局；冻融后囊胚腔的扩张程度越好，其发育潜能越高，显著改善妊娠结局。
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