淋巴上皮瘤样癌42例临床病理分析及文献复习

摘要

目的 探讨淋巴上皮瘤样癌(lymphoepithelioma-like carcinoma,LELC)的临床病理特点、诊断及鉴别诊断.方法 回顾性分析42例LELC的临床资料、病理特点和免疫组织化学染色结果,并复习相关文献.结果 42例LELC中,发生于涎腺25例、胃3例、食管3例、肝2例、纵膈2例、眼眶2例、肺2例、甲状腺1例、膀胱1例、子宫1例.HE染色显微镜下形态相似,在丰富的淋巴细胞背景中见散在分布低分化或未分化的癌细胞,呈条索或巢团状排列,免疫组化显示癌细胞表达CK,间质反应性淋巴细胞表达CD3、CD20.结论 LELC好发于涎腺,其他部位如胃、食管、肝、纵膈、眼眶、肺、甲状腺、膀胱、子宫等部位也可发生.%Objective To explore the clinicopathological features of the lymphatic epithelioma carcinoma (lymphoepithelioma-like carcinoma, LELC) and its diagnosis and differential diagnosis. Methods The clinical data, pathological features and immunohistochemical staining results of 42 patients with LELC were retrospectively analyzed, with the review of the relevant literature. Results Among 42 cases, 25 cases occurred in salivary glands, 3 cases occurred in stomach, 3 cases occurred in esophagus, 2 cases occurred in liver, 2 cases occurred in mediastinal, 2 cases occurred in eyes, 2 cases occurred in lung, 1 case occurred in thyroid, 1 case occurred in bladder, 1 case occurred in uterus. The microscopic morphology of the cases are similar, poorly differentiated or undifferentiated cancer cell line or nest scattered in the distribution of lymphocyte interstitium, CK positive cells located in cancer cells, while CD3, CD20 positive cells located in interstitial reactive lymphocytes. Conclusion LELC usually occurs in salivary glands, can also occur in other parts, such as the stomach, esophagus, liver, mediastinum, eye, lung, thyroid, the bladder and uterus.