老年2型糖尿病患者下肢深静脉血栓形成的相关危险因素

摘要

目的 研究老年2型糖尿病(T2DM)下肢深静脉血栓形成的危险因素.方法 对60～86岁的45例T2DM非血栓患者、40例非糖尿病下肢深静脉血栓患者以及35例T2DM伴下肢深静脉血栓形成患者进行病例对照研究.收集患者的血糖、血脂及血小板等22项资料,对上述指标先以单因素分析筛选出有统计学意义的危险因素,再进行Logistic 逐步回归分析.结果 糖尿病血栓组空腹血糖[(7.65±2.05)mmol/L]及餐后2小时血糖[(12.10±3.28) mmol/L]较糖尿病非血栓组和非糖尿病血栓组高(P<0.01);糖尿病血栓组血小板[(192.34±96.38) mmol/L]较非糖尿病血栓组和糖尿病非血栓组高(P<0.01);下肢深静脉血栓形成与餐后2小时血糖及血小板呈正相关(P<0.05);与服用阿司匹林呈负相关(P<0.01).结论 糖尿病是下肢深静脉血栓形成的危险因素之一,抗血小板治疗是防治糖尿病血栓形成的有效方法.%Objective To study the risk factors associated with lower limb deep venous thrombosis in elderly patients with type 2 dialetes mellitus (T2DM).Methods 45 elderly non-venous thrombosis patients with T2DM ,40 elderly non-diabetic patients with lower limb deep venous thrombosis,and 35 elderly lower limb deep venous thrombosis people with T2DM were selected, patients' data including blood glucose ,blood lipids,and platelet etc.Several statistically significant risk factors were screened out with univariate statistic, then independent risk factors were determined with stepwise logistic regression analysis.Results The degree of fasting blood glucose and 2 h-postprandial blood glucose were higher in group of deep venous thrombosis with T2DM than those of control group ( P ＜0.0l ).The degree of platelet was higher in group of deep venous thrombosis with T2DM than that of control group ( P ＜0.01 ).Lower limb deep venous thrombosis had positive correlation with 2 h-postprandial blood glucose and platelet ( P ＜ 0.05 ), and negative correlation with aspirin ( P ＜ 0.01 ).Conclusions T2DM is one of the risk factors for lower limb deep venous thrombosis.Anfi-platelet therapy is an effective way against lower limb deep venous thrombosis with T2DM.