目的 探讨DNA结合抑制因子-1(Id-1)在子宫内膜腺癌组织中的表达状态及与雌激素受体(ER)α之间的关系.方法 免疫组化法检测56例子宫内膜腺癌、18例子宫内膜不典型增生、20例正常子宫内膜组织中Id-1及ERα蛋白表达.结果 在正常子宫内膜组织、子宫内膜不典型增生及子宫内膜癌中Id-1表达逐渐增强(P＜0.05),ERα表达则逐渐减少(P＜0.05).Id-1蛋白阳性表达与组织分化程度及浸润肌层深度、手术病理分期有关(P＜0.05).ERα阳性表达与浸润肌层深度有关(P＜0.05).Id-1高表达患者的5年生存率低,但两组生存率差别无显著性意义(P＞0.05).Id-1与ERα表达之间呈正相关(r=0.284,P =0.034 ).结论 Id-1在子宫内膜癌中存在着过表达,并且可能与ERα协同参与了子宫内膜腺癌的发生发展.%Objective To study the expression of inhibitors of DNA binding-1 (Id-1) in endometrial adenocarcinoma and its corre lation with ERα. Methods Id-1 and ERα proteins were analyzed using immunohistochemistry in 56 patients with endometrial adenocarcinoma, 20 patients with normal endometria and 18 patients with atypia hyperplasia. Results The level of Id-1 expression was found in an increased order, while ERα was decreased from normal endometria to atypia hyperplasia, and then to endometrial adenocarcinoma( all P ＜0. 05). The expression of Id-1 was significantly correlated with the histological grade, clinical stage and depth of myometrial invasion ( P ＜0. 05 ). ERα expression was significantly correlated with the depth of myometrial invasion ( P ＜0. 05 ). There was no association between the expression of Id-1 and survival time (P ＞ 0. 05 ). Id-1 expression was positively correlated with ERα in endometrial adenocarcinomas( r =0. 284, P = 0.034 ). Conclusions The expression of Id-1 is up-regulated in endometrial adenocarcinoma, and Id-1 coexpression with ERαmay take part in the progression of endometrial adenocarcinoma.
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