泮托拉唑对应激性溃疡患者热休克蛋白70含量的影响

摘要

Objective To investigate the effect of pantoprazole on the content of HSP70 in the stress ulcer patients and its possible mechanism. Methods A total of 62 patients with stress ulcer were randomly divided into observation group and control group. Patients in the observation group were treated with pantoprazole 40 mg iv twice a day while those in the control group were treated with famotidine, 40 mg iv twice a day. Treatment started from the ulcer onset to a week after the color alteration of gastric juice drainage from brownish to yellow. Patients' venous blood was collected at the onset of brownish drainage ( U0), 1 week treatment of gastric acid secretion inhibitors ( U1 ) and 1 week after drainage color alteration (U2). Ten healthy patients were enrolled as normal group and blood samples were collected (as U0). The content of HSPT0 and its duration were compared. Results The content of HSP70 at U0 in observation group and control group was obviously higher than that in normal group (P ＜ 0.05 ). The content of HSP70 at U1 was obviously higher than that at U0 (P ＜ 0.05) , the content of HSP70 at U1 in observation group was significantly higher than that in control group (P ＜ 0.05), the content of HSP70 at U2 in observation and control group was lower than that at U0 (P ＜ 0.05). The content of HSP70 at U2 in observation group was lower than that in the control group (P ＜0. 05 ). The duration of HSP-70 present in the observation group was shorter than that in the control group (P ＜ 0.05 ).Ulcer healed significantly faster in the observation group than in the control group. Conclusion Pantoprazole can enhance the level of HSP70 in stress ulcer patients and help fast healing of ulcer. The mechanism of pantoprazole healing stress ulcer could be associated with enhanced level of HSP70.%目的 研究泮托拉唑对应激性溃疡患者热休克蛋白70含量的影响,为探明其预防应激性溃疡的新机制提供依据.方法 将符合纳入标准的62例应激性溃疡患者随机分为观察组和对照组.两组患者出现应激性溃疡时即开始用药物治疗:观察组泮托拉唑40 mg静滴,2次/d,对照组法莫替丁40 mg静滴,2次/d.疗程为开始至胃液引流液转为淡黄色并巩固1周的时间.收集3个时间点(刚出现咖啡色引流物、运用抑酸剂1周、引流胃液转黄后1周)患者的静脉血液 (分别定义为U0、U1、U2期).同时选择无消化道应激性溃疡出血10例患者作为正常组,收集其静脉血作为正常对照(相当于U0期).观察比较观察组及对照组患者U1、U2期及正常组HSP70的表达.比较观察组和对照组患者引流胃液转为淡黄色所需平均时间.结果 观察组与对照组患者U0期HSP70含量明显高于正常组,U1期明显高于U0期(P<0.05),观察组患者U1期HSP70含量明显高于对照组(P<0.05),观察组和对照组U2期HSP70含量明显低于U1期(P<0.05),观察组患者U2期HSP70含量明显高于对照组(P<0.05).观察组引流胃液转为淡黄色所需平均时间明显短于对照组,观察组患者应激性溃疡愈合速度明显快于对照组.结论 泮托拉唑能提高应激性溃疡患者热休克蛋白70表达,促进溃疡愈合速度较法莫替丁迅速,泮托拉唑愈合溃疡机制之一可能与提高HSP70表达有关.