Objective To investigate the characteristics of serum homocysteine, folic acid and vitamin B12 levels in patients with atrophic gastritis. Method According to the detection results, 128 cases of atrophic gastritis patients and 45 healthy persons were divided into 88 cases of atrophic gastritis patients with Hp infection (group A), 40 cases of atrophic gastritis patients without Hp infection (group B) and 45 healthy persons without Hp infection (group C), compared three groups of serum levels of homocysteine, folic acid and vitamin B12. Result Group A of patients with serum homocysteine levels were significantly higher than group B, folic acid and vitamin B12 levels were signiifcantly lower than group B, the differences were statistically signiifcant (P<0.05). Group B serum homocysteine levels were signiifcantly higher than group C, the difference was signiifcant (P < 0.05), but group B with folic acid, vitamin B12 levels compared with group C had no signiifcant difference (P>0.05). Conclusion Serum homocysteine, folic acid and vitamin B12 levels inpatients with atrophic gastritis are signiifcantly higher than normal people, and Hp infection can cause folic acid and vitamin B12 deifciency and increase serum homocysteine levels, promote the occurrence of atrophic gastritis.%目的：探讨萎缩性胃炎患者血清同型半胱氨酸、叶酸及维生素B12水平及其特点。方法根据检测结果将128例萎缩性胃炎患者和45例体检健康者分为Hp感染阳性的萎缩性胃炎组（A组）88例和Hp感染阴性的萎缩性胃炎组（B组）40例，Hp感染阴性的健康组（C组）45例。比较三组研究对象血清同型半胱氨酸、叶酸和维生素B12水平。结果 A组患者血清同型半胱氨酸水平显著高于B组，叶酸及维生素B12水平显著低于B组，差异均具有显著性（P＜0.05）。B组患者血清同型半胱氨酸水平显著高于C组，差异有显著性（P＜0.05），但B组叶酸、维生素B12水平与C组相比差异无显著性（P＞0.05）。结论萎缩性胃炎患者的血清同型半胱氨酸水平显著高于健康者，而Hp可以导致体内叶酸和维生素B12缺乏，使血清同型半胱氨酸水平升高，促进萎缩性胃炎的发生。
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