目的：探讨妊娠高血压综合征（PIH）患者血清硫化氢（H2S）水平变化及其临床意义。方法43例PIH患者作为观察组，43例无PIH孕妇作为对照组，对比两组产妇血清H2S水平；根据病情程度将观察组患者按妊娠高血压严重程度分为妊娠高血压、轻度子痫前期、重度子痫前期，比较不同程度PIH患者血清H2S水平差异。结果观察组患者血清H2S水平显著低于对照组（P＜0.01）；妊娠高血压患者血清H2S水平显著高于轻度子痫前期（P＜0.01），轻度子痫前期患者血清H2S水平显著高于重度子痫前期（P＜0.01）；观察组患者分娩前后血清H2S水平比较差异无显著性（P＞0.05）。结论 H2S水平检测能够在一定程度上为PIH的诊断提供相应证据，同时对于PIH病情监测也具有一定临床价值。%Objective To discuss the clinical signiifcance and changes of H2S in patients with PIH. Method 43 patients with PIH were divided into observation group, and 43 patients without PIH were divided into control group, then the serum concentrations of H2S were contrasted between two groups;and 43 patients with PIH were divided into gestational hypertension, mild pre-eclampsia gand severe pre-eclampsia according to state of an illness, then the serum concentrations of H2S were contrasted;and the serum concentrations of H2S were contrasted before and after childbirth. Result The serum concentrations of H2S in observation group were signiifcantly lower than control group (P<0.01);and gestational hypertension group were signiifcantly higher than mild pre-eclampsia group (P < 0.01), and mild pre-eclampsia group signiifcantly higher than severe pre-eclampsia group (P < 0.01);but no signiifcantly difference before and after childbirth in patients with PIH. Conclusion H2S levels can provide evidence for the diagnostic PIH, and has clinical value for the monitoring of PIH.
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