前列地尔联合复方甘草酸苷治疗重度慢性乙型肝炎合并淤胆的疗效及对血清生化指标的影响

摘要

目的：探讨前列地尔联合复方甘草酸苷治疗重度慢性乙型肝炎合并淤胆的临床疗效。方法将92例重度慢性乙型肝炎合并淤胆患者采用数字表法随机分为两组，两组均给予复方甘草酸苷注射液，另外观察组在此基础上加用前列地尔，比较两组临床疗效及血清生化指标变化。结果观察组总有效率为89.13%，显著高于对照组（76.09%）（χ2＝7.83，P＜0.05）；观察组治疗后总胆红素（TBIL）、直接胆红素（DBIL）、丙氨酸氨基转移酶（ALT）、γ-谷氨酰转肽酶（γ-GT）和碱性磷酸酶（AKP）指标分别为（68.78±7.82）μmol/L、（54.64±6.68）μmol/L、（64.57±8.97）IU/L、（59.62±7.34）IU/L和（60.23±8.22）IU/L，均显著低于治疗前[（265.63±11.78）μmol/L、（138.49±11.29）μmol/L、（557.62±21.23）IU/L、（157.72±10.31）IU/L 和（170.38±11.20）IU/L]（t＝11.23、10.42、10.63、9.88、10.68，P＜0.05）和对照组[（153.68±8.62）μmol/L、（137.44±9.31）μmol/L（、152.02±12.33）IU/L（、114.82±9.21）IU/L和（106.83±9.01）IU/L]（t＝8.38、8.01、7.92、8.30、7.20，P＜0.05）。结论前列地尔联合复方甘草酸苷治疗重度慢性乙型肝炎合并淤胆具有显著疗效。%ObjectiveTo investigate the effect of alprostadil combined wih glycyrrhizin in treatment of severe chronic cholestatic hepatitis B.Methods92 patients with severe chronic cholestatic hepatitis B combined were divided into two groups by using a random number table metod. Two groups were given glycyrrhizin injection while the observation group were treated with alprostadil in addton. The clinical efifcacy and serum biochemical parameters changes were compared between the two groups.ResultsThe observation group's total effective rate was 89.13%, signiifcantly higher than the control group's 76.09% (χ2=7.83,P<0.05);The observation group's indicators of TBIL, DBIL, ALT, γ-GT and AKP after treatment were (68.78±7.82)μmol/L, (54.64±6.68) μmol/L, (64.57±8.97) IU/L, (59.62±7.34) IU/L and (60.23±8.22) IU/L which were signiifcantly lower than before treatment's ( 265.63±11.78) μmol / L, (138.49±11.29) μmol / L, (557.62±21.23) IU/L, (157.72±10.31) IU/L and (170.38±11.20) IU/L (t=11.23, 10.42, 10.63, 9.88, 10.68,P<0.05) and control group's (153.68±8.62) μmol/L, (137.44±9.31) μmol/L, (152.02±12.33) IU/L, (114.82±9.21) IU/L and (106.83±9.01) IU/L (t=8.38, 8.01, 7.92, 8.30, 7.20,P<0.05).ConclusionAlprostadil combined with glycyrrhizin has a signiifcant effect in treatment of severe chronic cholestatic hepatitis B.