奥硝唑联合腔治捷治疗慢性牙周炎临床效果分析

摘要

Objective To investigate the clinical efficacy of Ornidazole combined with Qiang zhi jie in the treatment of chronic periodontitis and its' influence on the inflammatory cytokines in gingival crevicular fluid. Method From December 2014 to December 2016, 140 cases of chronic periodontitis patients in Chengdu Second People's Hospital were divided into observation group (n=70) and control group (n=70) according to the random number table method, all patients underwent periodontal therapy, and treated with Ornidazole, on the basis of it, observation group patients were injected Qiang zhi jie after washing periodontal pocket. After 4 weeks of treatment, the clinical efficacy of the two groups was evaluated, the periodontal probing depth (PD), clinical attachment loss (CAL), plaque index (PLI) and bleeding index (BI), high sensitivity C reactive protein (hs-CRP), tumor necrosis factor alpha (TNF-α) and interleukin (IL)-17, IL-21 were measured before and after treatment, the adverse reactions during the treatment of the two groups were observed. Result After treatment, the total effective rate of observation group was significantly higher than that of control group (P<0.05). The levels of PD, CAL, BI and PLI in the two groups were significantly lower than those before treatment (P<0.05), and the level in observation group were significantly lower than those in the control group (P<0.05). The levels of hs-CRP, TNF-α, IL-17, IL-21 in the two groups were significantly lower than those before treatment (P<0.05), and the levels of above indexes of observation group were significantly lower than those of control group (P<0.05). There were no serious adverse events during the treatment in the two groups. Conclusion Compared with Ornidazole alone, Ornidazole combined with Qiang zhi jie can effectively improve the periodontal index of chronic periodontitis patients and reduce the level of inflammatory cytokines, it's safe and effective.%目的 探讨奥硝唑联合腔治捷治疗慢性牙周炎的临床效果及其对患者龈沟液炎性细胞因子的影响.方法 将成都市第二人民医院2014年12月至2016年12月收治的140例慢性牙周炎患者按照随机数表法分为观察组(70例)和对照组(70例),两组患者均行牙周基础治疗,并口服奥硝唑,观察组患者在此治疗基础上于冲洗牙周袋后注入腔治捷.治疗4周后,评价两组患者的临床疗效;比较两组患者治疗前后牙周探诊深度(probing depths,PD)、临床附着丧失(clinical attachment loss,CAL)、菌斑指数(plaque index,PLI)、出血指数(bleeding index,BI)以及高敏C反应蛋白(high sensitivity C reactive protein,hs-CRP)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素(interleukin,IL)-17、IL-21水平;观察两组患者治疗期间不良反应发生情况.结果 治疗后,观察组治疗总有效率显著高于对照组(P<0.05);两组患者PD、CAL、BI、PLI均明显低于本组治疗前(P<0.05),且观察组患者上述指标水平均显著低于对照组(P<0.05);两组患者龈沟液中hs-CRP、TNF-α、IL-17、IL-21水平均明显低于治疗前(P<0.05),且观察组患者上述指标水平均显著低于对照组(P<0.05);两组患者治疗过程中均未发生严重不良反应.结论 与单用奥硝唑比较,奥硝唑联合腔治捷更能有效改善慢性牙周炎患者的临床指标,降低炎性细胞因子水平,安全有效.