IL-18基因多态性与原因不明复发性流产关联性的meta分析

摘要

Objective:To investigate the relevance of polymorphism of interleukin 18 (IL-18) gene rs187238 and the susceptibility of unexplained recurrent spontaneous abortion (URSA).Methods:The related articles were searched from database such as PubMed,Embase,and Wanfang up to December 18,2016.Case-control studies that related to rs10830963 variant and the risk of URSA were included based on inclusion and exclusion criteria,and data were extrac ted independently by two reviewers.RevMan5.1 was used to analyze the value of pooled odds ratio(0R),to conduct subgroup analysis,to test publication bias,and to do sensitivity analysis.Results:A total of 6 articles matched the inclusion criteria and were involved in this Meta analysis,which included 1435 women with URSA and 1377 normal women.Homozygous mutant CC genotype carriers had significant higher risk of URSA than that of homozygous wild type GG allele carriers,with OR value (1.79,95％ CI 1.03-3.10).Moreover,the analysis of recessive genetic model (CC vs GG+GC)indicated that the pooled OR value and 95％ CI were 1.80 and 1.08-3.01.Conclusion:This Meta a nalysis showed that the rs187238 polymorphism might serve as a risk factor of URSA.%目的:探讨白细胞介素18(IL-18)基因rs187238多态性与原因不明复发性流产(URSA)发病风险之间的关联.方法:根据检索策略,通过Pubmed、Embase、web of SCI及万方数据库进行相关文献检索,按照既定的文献纳入及排除标准进行筛选,利用meta分析方法综合分析国内外关于IL-18基因多态性与URSA相关性的病例对照研究资料,计算IL-18 rs187238多态性与URSA之间的合并OR值及其95％CI,并进行亚组分析、发表偏移及敏感性分析.结果:共有6篇文献纳入分析中,包括URSA1435例及正常对照1377例.分析显示rs187238的CC基因型的合并OR值为1.79(95％CI 1.03～3.10),即突变型CC携带者较野生型GG携带者发生URSA的风险显著增高,隐性遗传模型CC/GG+ GC分析显示OR值为1.80(95％CI 1.08～3.01).结论:IL-18基因rs187238多态性与URSA的发生存在关联.