Objective To discuss the predictive value of atherogenic index of plasma (AIP) to major adverse cardiovascular events (MACE) in patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI).Methods CHD patients (n=202) undergone success PCI and volunteered to receive follow-up were chosen from Dec. 2014 to Dec. 2015. The indexes of AIP, blood biochemistry and ultrasonography were detected. After follow-up for 1 y, all patients were divided into MACE group (n=31) and non-MACE group (n=171). The clinical materials, and indexes of blood biochemistry, ultrasonography and AIP were compared between 2 groups. The predictive value of AIP to MACE was reviewed by using receiver operating characteristic curve (ROC). Results The level of AIP was significantly higher in MACE group than that in non-MACE group (P<0.05). The multi-factor Logistic regression analysis showed that higher AIP level was an independent risk factor of MACE after PCI (OR=7.844,P<0.05). The area under curve (AUC) in ROC for predicting MACE by AIP was 0.860 (95%CI:0.782~0.938,P<0.05). When AIP level was 0.21, its sensitivity was 77.42%, specificity was 95.32%, accuracy was 93.56%, positive predictive value was 75.00% and negative predictive value was 95.88%.Conclusion The detection of AIP which is economical, has some predictive value to incidence of MACE. When AIP level is over 0.21, the risk of MACE will increase in CHD patients after PCI.%目的 探讨血浆致动脉硬化指数(AIP)对冠心病患者行冠状动脉介入治疗(PCI)后主要不良心血管事件(MACE)发生的预测价值.方法 选取2014年12月~2015年12月于锦州市中心医院成功施行PCI并自愿接受随访的冠状动脉粥样硬化性心脏病(冠心病)患者202例,检测血浆致动脉硬化指数AIP、血生化及超声等指标.术后随访1年,根据是否发生MACE,分为MACE组(31例)及无MACE组(171例),比较两组患者临床资料、血生化、超声、AIP等指标,并运用受试者工作特征曲线(ROC)评价AIP对MACE的预测价值.结果 MACE组患者AIP水平显著高于无MACE组,差异有显著统计学意义(P<0.05);Logistic多因素回归分析显示,AIP升高是PCI后MACE发生的独立危险因素(OR=7.844,P<0.05);在AIP预测MACE能力的ROC曲线中,其曲线下面积为0.860(95%CI:0.782~0.938,P<0.05);当AIP取0.21时,其预测MACE的敏感性为77.42%,特异性为95.32%,准确性为93.56%,阳性预测价值为75.00%,阴性预测价值为95.88%.结论 方便、经济的AIP检测对冠心病患者PCI后MACE的发生具有一定的预测价值,尤其是AIP水平超过0.21时患者PCI后发生MACE的风险较大.
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