血小板-淋巴细胞比值与冠状动脉慢血流之间关系的探究

摘要

Objective To discuss the relationship between platelet-lymphocyte ratio (PLR) and coronary slow-flow (CSF).Methods CSF patients (n=46) were chosen as CSF group from the Department of Cardiology of People's Hospital affiliated to Hubei University of Medicine from Apr. 2015 to Dec. 2016. Meanwhile the patients (n=48) with normal outcomes of coronary angiography (CAG) were randomly chosen as control group. The general clinical materials were collected, classification and count of blood cells were detected and value of PLR was calculated.Results The level of PLR was higher in CSF group than that in control group (141.44±22.97vs. 123.88±21.86), and level of mean platelet volume (MPV) was significantly higher in CSF group than that in control group [(10.93±0.93) fLvs. (10.58±0.74) fL, allP<0.05]. The Logistic regression analysis showed that higher PLR was an independent risk factor of CSF (OR=1.036, 95%CI: 1.015-1.058,P<0.001).Conclusion The levels of PLR and MPV increase significantly in CSF patients, which indicates that platelet dysfunction and chronic inflammatory reactions may be the important pathogenesis of CSF, and higher PLR is an independent risk factor of CSF.%目的 探索血小板-淋巴细胞比值(PLR)与冠状动脉慢血流(CSF)之间的关系.方法 入选自2015年4月~2016年12月于湖北医药学院附属人民医院心内科住院,行冠状动脉造影确认的CSF患者46例,归入CSF组;并随机选取同期经冠状动脉造影确认的正常的患者48例作为对照组.提取一般临床资料结果,检测其血细胞分类并计数,同时计算其PLR数值.结果 CSF患者PLR水平较对照组明显升高(141.44±22.97vs.123.88±21.86),平均血小板体积(MPV)水平亦明显高于对照组[(10.93±0.93)fLvs.(10.58±0.74)fL],差异均具有统计学意义(P均<0.05).Logistic回归分析显示PLR升高(OR=1.036,95%CI:1.015~1.058,P<0.001)为CSF的独立危险因素.结论 PLR及MPV在CSF患者中明显升高,提示血小板功能紊乱和慢性炎症反应可能为CSF发病的重要机制,且PLR升高为CSF的独立危险因素.