Objective To investigate correlation between epicardial adipose tissue thickness and coronary artery disease by ultrasound imaging. Methods 98 hospitalized patients from January 2013 to December 2016 underwent coronary artery ultrasound examination for unclear causes of angina, myocardial infarction and chest pain were selected. the clinical data of patients were collected. Epicardial adipose tissue thickness were measured by echocardiographic. The Gensini score was used to evaluate the severity of coronary artery lesions in patients with coronary heart disease (CHD) patients. Patients were divided into CHD group and non-CHD group, CHD group was divided into mild group, moderate group and severe group according to severity of CHD. Results There were no significant differences between CHD group and non- CHD group with respect of sex, age, systolic blood pressure, fasting blood glucose, total cholesterol, three triglyceride, high density lipoprotein and fasting insulin (P>0.05). body mass index, waist circumference, coronary heart disease patients with diastolic blood pressure, low density lipoprotein and epicardial adipose tissue (EAT) thickness were significantly higher in CHD group (P<0.05). The EAT of CHD group was thicker than that of non-CHD group, and the greater the degree of coronary artery lesion, the greater the EAT thickness, the difference was statistically significant (P<0.05). Result of Spearson correlation analysis showed that EAT thickness and low density lipoprotein, diastolic blood pressure, body mass, waist circumference was positively correlated. Result of logistic regression analysis showed that EAT thickness was independent risk factor of coronary artery disease (P<0.05). Conclusion Epicardial adipose tissue thickness is positively correlated with the severity of coronary artery disease. It is an independent risk factor for coronary artery disease. Measurement of epicardial adipose tissue thickness is simple, noninvasive and worthy of clinical promotion.%目的 评价经超声影像测量的心外膜脂肪组织厚度与冠状动脉病变的相关性.方法 选择2013年1月~2016年12月于河南理工大学第一附属医院因不明原因心绞痛、心肌梗死、胸痛接受冠状动脉血管内超声检查的患者98例,采集患者临床资料,超声测量心外膜脂肪组织厚度,采用Gensini评分法对患者冠状动脉病变严重程度进行测评,根据患者是否发生冠状动脉粥样硬化性心脏病(冠心病)将患者分为冠心病组和非冠心病组,冠心病组患者根据病变严重程度分为轻度、中度和重度病变组.结果 冠心病组与非冠心病组在性别、年龄、收缩压、空腹血糖、总胆固醇、三酰甘油、高密度脂蛋白及空腹胰岛素等方面比较,差异无统计学意义(P>0.05);冠心病组患者的体质指数、腰围、舒张压、低密度脂蛋白、心外膜脂肪组织(EAT)厚度等显著高于非冠心病组患者,差异有统计学意义(P<0.05);冠心病组患者EAT较非冠心病组患者厚,且冠状动脉病变程度越重,患者EAT值越大,差异有统计学意义(P<0.05);Spearson相关性分析结果显示,EAT厚度与低密度脂蛋白、舒张压、体质指数、腰围呈正相关;Logistic回归分析显示,EAT厚度是冠状动脉病变的独立危险因素(P<0.05).结论 在众多冠心病危险因素中,EAT厚度与冠状动脉病变严重程度显著相关,可能是评价冠心病风险的辅助指标,超声测量心外膜脂肪组织厚度简易无创,值得临床推广.
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