中国汉族人群血管紧张素原基因T174M位点多态性与原发性高血压关系的Meta分析

摘要

目的 探讨中国汉族人群血管紧张素原(AGT)基因T174M位点多态性与原发性高血压的关联.方法 计算机检索Medline、Embase、中国期刊全文数据库(CNKI)、万方数据库(Wanfang)和重庆维普数数据库(VIP),收集满足我们要求的病例-对照研究.检索时间限定在2017年10月31日之前.然后用RevMan 5.0软件进行一系列综合定量分析,包括计算合并的比值比(OR)、95%的可信区间(CI)、异质性的检验以及敏感性分析.通过Stata 10.0软件来检测发表偏倚的影响.结果 最终纳入15个病例对照研究,共计3730例原发性高血压患者和3273例正常血压者.在中国汉族人群的总体分析和按照地域划分的亚组分析中,没有发现T174M位点多态性与中国汉族人群原发性高血压相关性有统计学意义.而在另外一个亚组中,在显性基因模型下,我们发现T174M位点多态性与较严重的原发性高血压人群(收缩压≥160 mmHg,舒张压≥95 mmHg)的相关性有统计学意义(MM+MT vs. TT: OR=1.82, 95%CI:1.20~2.76,P=0.005).结论 尚无足够证据去证明血管紧张素原基因T174M位点多态性与中国汉族人群原发性高血压易感性有关.%Objective To investigate the relationship between the angiotensinogen (AGT) gene T174M polymorphism and essential hypertension (EH) in the Han Chinese population. Methods To find out all the case-control studies that met the inclusion criteria, we conducted a computer retrieval of Medline, Embase, CNKI, Wanfang and VIP databases prior to August 2017. The association between the T174M polymorphism and hypertension risk was examined through quantitative analysis by RevMan 5.0 software. The analysis included the calculation of the pooled odds ratio (OR) as well as 95% confidence interval (CI). The evaluation of the between-study heterogeneity and the performance of sensitivity analysis. The Stata 10.0 software was used to assess the publication bias. Results According to the inclusion criteria, 15 eligible articles involving 3730 cases and 3273 controls were included in the present study. Then, we found no statistical association between the T174M polymorphism and EH risk in all subjects or in the subgroups by area. However, a significant association was observed between the T174M polymorphism and a hypertensive group (systolic blood pressure ≥ 160 mmHg and/or diastolic blood pressure ≥ 95 mmHg) in the dominant genetic model (MM+MT vs. TT: OR=1.82, 95%CI: 1.20~2.76, P=0.005). Conclusion There are not enough evidence for the genetic association of the AGT gene T174M polymorphism with hypertension risk in the Han Chinese population.